Rubiaceae type cyclic peptide diglycoside and its preparation method and application

A technology of Rubiaceae and Rubia genus, applied in the field of extraction and separation of natural organic compounds, can solve the problems that have not yet been reported on Rubiaceae type cyclic peptide diglycosides, and achieve good application prospects and good technical application prospects
CN109134618BActive Publication Date: 2021-12-28GUANGXI INST OF BOTANY THE CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GUANGXI INST OF BOTANY THE CHINESE ACAD OF SCI
Publication Date
2021-12-28

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Abstract

The invention discloses a rubiaceae type cyclic peptide diglucoside as well as its preparation method and application. The preparation method of the Rubiaceae type cyclic peptide diglycoside is as follows: using the stem and / leaf of the Rubiaceae Rubio genus Arthropodium as raw materials to obtain its extract, and the obtained extract is sequentially passed through a macroporous resin column, a silica gel column, a reversed-phase Silica gel column separation and purification, namely; when separated and purified by a macroporous resin column, the eluent is a mixed solvent composed of methanol or ethanol and water; when separated and purified by a silica gel column, the eluent is composed of chloroform and methanol mixed solvent; when separated and purified by a reverse-phase silica gel column, the eluent is a mixed solvent composed of methanol or acetonitrile and water. The applicant's experimental results show that the above-mentioned Rubiaceae type cyclic peptidoside has inhibitory activity of NF-κB signaling pathway and can be used as an inhibitor of NF-κB signaling pathway. The Rubiaceae type cyclic peptidoside has a structure shown in the following formula (I):
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Description

technical field

[0001] The invention relates to the extraction and separation of natural organic compounds in plants, in particular to a rubiaceae type cyclic peptide diglycoside and its preparation method and application. Background technique

[0002] Cyclic peptides are a class of cyclic compounds mainly composed of amino acids connected by peptide bonds. At present, there are about 500 kinds of cyclic peptide compounds found in nature, and many cyclic peptides have good biological activities. Rubiaceae-type cyclic peptides are a class of bicyclic or monocyclic cyclohexyl peptides discovered from Rubiaceae. At present, about 40 Rubiaceae-type cyclic peptide compounds have been discovered, including monoglycosides and dimers.

[0003] NF-κB signaling pathway is one of the classic and important signaling pathways in cells. Ranjan Sen and David Baltimore first discovered the nuclear transcription factor NF-κB in 1986. It is a protein factor that can specifically bind to the...

Claims

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