NMN nano microspheres coated with konjac glucomannan as well as preparation process and application thereof

A technology of konjac glucomannan and mannan, which is applied to NMN nano-microspheres coated with konjac glucomannan and its preparation process and application field, which can solve the problems of inability to take orally, unstable chemical properties of NMN, and difficulty in storage, etc. question

Active Publication Date: 2019-02-19
HOBOOMLIFE BIO TECH SHENZHEN CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] For this reason, the technical problem to be solved by the present invention is that NMN has unstable chemical properties, is difficult to store, and cannot be taken orally, thereby proposing a coated konjac glucomannan that has improved stability, is easy to store, can be taken orally, can be produced on a large scale, and can be used NMN nanospheres of polysaccharides and its preparation technology and application

Method used

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  • NMN nano microspheres coated with konjac glucomannan as well as preparation process and application thereof
  • NMN nano microspheres coated with konjac glucomannan as well as preparation process and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] This embodiment provides a kind of NMN nano-microspheres coated with konjac glucomannan (KGM), which includes NMN nano-microspheres, and the outside of the NMN nano-microspheres is coated with KGM nano-microspheres, wherein the NMN nano-microspheres The particle diameter of the microspheres is 700nm, and the particle diameter of the KGM nanospheres is 600nm, and other preparation auxiliary materials are also included. In this embodiment, the KGM nanospheres are made from konjac glucomannan.

[0031] This implementation also provides a process for preparing NMN nano-microspheres coated with konjac glucomannan, which includes the following steps:

[0032] S1. Disperse 10 parts by weight of NMN nano microspheres in the preparation auxiliary materials to obtain a premix, wherein the auxiliary materials include 60 parts by weight of konjac glucomannan nanospheres, 6 parts of polyvinylpyrrolidone, 14 parts of micro Crystalline cellulose, 5 parts calcium polyphosphate, 10 part...

Embodiment 2

[0046] This embodiment provides a kind of NMN nano-microspheres coated with konjac glucomannan (KGM), which includes NMN nano-microspheres, and the outside of the NMN nano-microspheres is coated with KGM nano-microspheres, wherein the NMN nano-microspheres The particle diameter of microsphere is 500nm, and the particle diameter of described KGM nano-microsphere is 200nm, also includes other preparation auxiliary materials, and in the present embodiment, described KGM nano-microsphere is quaternized konjac glucomannan (QKGM), A mixture of carboxymethyl konjac glucomannan (CKMG).

[0047] This implementation also provides a process for preparing NMN nano-microspheres coated with konjac glucomannan, which includes the following steps:

[0048] S1, disperse 1 weight part of NMN nano microspheres in the preparation auxiliary material (the preparation process of the NMN nano microspheres is the same as in Example 1) to obtain a premix, wherein the auxiliary materials include 80 part...

Embodiment 3

[0057] This embodiment provides a kind of NMN nano-microspheres coated with konjac glucomannan (KGM), which includes NMN nano-microspheres, and the outside of the NMN nano-microspheres is coated with KGM nano-microspheres, wherein the NMN nano-microspheres The particle diameter of microsphere is 1000nm, and the particle diameter of described KGM nano-microsphere is 1000nm, also includes other preparation auxiliary materials, and in the present embodiment, described KGM nano-microsphere is deacetylated konjac glucomannan (da-KGM) .

[0058] This implementation also provides a process for preparing NMN nano-microspheres coated with konjac glucomannan, which includes the following steps:

[0059] S1. Disperse 20 parts by weight of NMN nanospheres in the preparation auxiliary material (the preparation process of the NMN nanospheres is the same as in Example 1) to obtain a premix, wherein the auxiliary materials include 20 parts of konjac in parts by weight Glucomannan nanospheres...

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Abstract

The invention discloses NMN nano microspheres coated with konjac glucomannan. The NMN nano microspheres comprise NMN nanospheres, wherein the NMN nanospheres re externally coated with konjac glucomannan nanospheres, a particle size of the NMN nanosphere is 500 to 1000 nm, and the particle size of the konjac glucomannan nanosphere is 200 to 1000 nm. The NMN with instable performance is externally coated with the konjac glucomannan (KGM) nanoparticles, and the KGM nanoparticles protect the NMN, so that the instability and easy decomposition of the NMN when in light or after being oxidized can beprevented. The NMN and the KGM are prepared into a coated complex, and the NMN can be slowly released in a given time, so that the NMN can be prevented from being immediately decomposed by the gastric acid. The composite nano microspheres can be used for producing oral preparations and for resisting the cancers. The invention also discloses a preparation process and application of the NMN nano microspheres coated with the konjac glucomannan. The preparation process is simple in procedures and mild in conditions; and the prepared nano microspheres can be widely applied to the production of anticancer drugs, healthcare drugs and pet drugs.

Description

technical field [0001] The invention belongs to the technical field of health product production, and relates to a health product containing NMN and its preparation and application, in particular to NMN nano-microspheres coated with konjac glucomannan and its preparation process and application. Background technique [0002] With the growth of people's age and the aging of the body, many health problems arise, which seriously affect people's quality of life. Such as vascular dysfunction, exercise capacity, decline in brain cognitive function, etc., and even Parkinson's and other diseases. [0003] Drugs aimed at improving health and quality of life have gradually been extensively studied in recent years. For example, nicotinamide mononucleotide (NMN) has been used in clinical trials by a joint research team of Japan's Kei University and the University of Washington in the United States in 2016. NMN has been confirmed in animal experiments to have the effect of reversing the...

Claims

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Application Information

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IPC IPC(8): A61K9/62A61K9/51A61K9/58A61K9/20A61K47/36A61K47/38A61K47/32A61K31/706A61P35/00A61P35/04A61P25/16A61P25/28A61P25/24
CPCA61K9/2027A61K9/205A61K9/2054A61K9/5138A61K9/5161A61K31/706A61P25/16A61P25/24A61P25/28A61P35/00A61P35/04
Inventor 王运刘喜元方秋杰陈娜叶小舟
Owner HOBOOMLIFE BIO TECH SHENZHEN CO LTD
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