Preparation method of herba houttuyniae formula granules

A formula granule, the technology of Houttuynia cordata, which is applied in the direction of pharmaceutical formula, medical preparations containing active ingredients, and devices for making medicines into special physical or ingestible forms, can solve the problems such as Houttuynia cordata formula granules that have not yet been seen , to achieve the effect of improving the physical dissolution transfer rate, preventing changes, and improving product quality

Pending Publication Date: 2019-04-05
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the preparation of Houttuynia formula granules by continuous dynamic countercurrent extraction process

Method used

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  • Preparation method of herba houttuyniae formula granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A preparation method of houttuynia formula granules, comprising the steps of:

[0042] a. Select Houttuynia cordata medicinal materials, vibrate and sieve to remove impurities, and crush them into 0.5cm particles to obtain Houttuynia cordata decoction pieces;

[0043] b. Wet the broken Houttuynia cordata decoction pieces with 2 times the amount of water, and continuously input them into the extraction tube of the spiral continuous countercurrent extraction machine (two-stage 10-section tube structure) from the front-end feeding port. Through a set of spiral structure, the material is continuously pushed forward to the slag outlet of the extraction tube for slag discharge, and 20 times the amount of 95°C hot water is continuously added to the end of each level of extraction tube for continuous countercurrent extraction for 1 hour. The hot water and the material are reversed Flow to the front end of the extraction tubes at all levels to discharge the liquid, collect the e...

Embodiment 2

[0048] Step c, the combined extract solution is cooled to 50°C and then filtered, and the filtrate is sterilized in an ultra-high temperature instantaneous sterilizer (UHT) at 150°C for 10 seconds, and then concentrated under reduced pressure at 60°C to obtain a relative density of 1.06 clear ointment;

[0049] All the other steps are the same as in Example 1.

Embodiment 3

[0051] A preparation method of houttuynia formula granules, comprising the steps of:

[0052] a. Select Houttuynia cordata medicinal materials, vibrate and sieve to remove impurities, and crush them into 0.5cm particles to obtain Houttuynia cordata decoction pieces;

[0053] b. Wet the broken Houttuynia cordata decoction pieces with 2 times the amount of water, and continuously input them into the extraction tube of the spiral continuous countercurrent extraction machine (two-stage 10-section tube structure) from the front-end feeding port. Through a set of spiral structure, the material is continuously pushed forward to the slag outlet of the extraction tube to discharge the slag, and 18 times the amount of 80°C hot water is continuously added to the end of the extraction tube at each level for continuous countercurrent extraction for 1 hour. The hot water and the material are reversed. Flow to the front end of the extraction tubes at all levels to discharge the liquid, colle...

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Abstract

The invention discloses a preparation method of herba houttuyniae formula granules. The preparation method comprises the steps that a, herba houttuyniae is crushed or cut up to obtain herba houttuyniae decoction pieces; b, the herba houttuyniae decoction pieces are continuously conveyed into a continuous dynamic countercurrent extractor, hot water is continuously and reversely added into the tailends of all levels of extraction pipes, continuous dynamic countercurrent extracting is conducted, an extracting solution is collected, and decoction medicine residues are discharged; c, the extracting solution is filtered, ultra-high temperature instantaneous sterilization is conducted, and filtrate is subjected to decompression concentration into sugarless paste; d, auxiliary materials are addedinto the sugarless paste, dissolving is conducted, and spray drying is conducted to obtain dry extract powder; and e, preparation auxiliary materials are added into the dry extract powder, and dry granulation is conducted to obtain the herba houttuyniae formula granules. According to the preparation method, a continuous countercurrent extraction, ultra-high temperature instantaneous sterilization, decompression concentration, spray drying and dry granulation production technology is adopted, all technological parameters are studied, thus the contents of effective constituents in the herba houttuyniae formula granules can reach the high level continuously and stably, it is ensured that the transfer rate of the active constituents is consistent with that of herba houttuyniae standard decoction, and the product quality of the herba houttuyniae formula granules is improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and in particular relates to a preparation method of Houttuynia cordata formula granules. Background technique [0002] Houttuynia cordata Houttuynia cordata Fresh whole herb or dried aerial part of Thunb. The fresh products can be harvested throughout the year, and the dried products can be harvested when the stems and leaves are lush in summer, and the flowers and spikes are long, and the impurities are removed and dried in the sun. Both the fresh and dry products of this product can be used as medicine. The dosage of the fresh product is doubled, and it is decocted or pounded into juice. Dysentery, pyretic stranguria, carbuncle sore. It has been reported in the literature that quercetin, one of the main active ingredients of Houttuynia cordata, has pharmacological effects such as antiviral, anti-inflammatory, and diuretic, which are consistent with its ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K9/16A61P31/12A61P29/00A61P7/10A61J3/00
CPCA61J3/00A61K9/16A61K36/78A61K2236/15A61K2236/331A61K2236/51A61K2236/53A61P7/10A61P29/00A61P31/12
Inventor 魏梅程学仁鲁云方朝缵张志鹏孙建焱钟文峰曾耀辉蔡盛康
Owner GUANGDONG YIFANG PHARMA
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