Preparation method of chrysanthemum formula granules

A technology of formula granules and chrysanthemum is applied in the field of preparation of chrysanthemum formula granules to achieve the effects of improving the extraction transfer rate and reducing degradation and damage.

Inactive Publication Date: 2019-04-05
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the preparation of chrysanthemum formula granules by continuous dynamic countercurrent extraction process

Method used

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  • Preparation method of chrysanthemum formula granules

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A preparation method of chrysanthemum formula granules, comprising the steps of:

[0042] a. Select the medicinal materials of chrysanthemum, shake and sieve to remove impurities, and crush them into 0.5cm particles to obtain chrysanthemum decoction pieces;

[0043] b. Moisten the crushed chrysanthemum decoction pieces with 2 times the amount of water, input them into the spiral continuous dynamic countercurrent extractor, add 20 times the amount of hot water at 95°C in reverse and extract continuously for 1 hour, collect the extract, and pass the chrysanthemum medicinal residues through Squeeze and recover part of the medicinal liquid and then discharge it, the recovered part of the medicinal liquid is combined with the extract; the input speed of the chrysanthemum decoction pieces is 100kg / h, and the flow rate of reversely adding hot water is 1000L / h;

[0044] c. The combined extracts are cooled to 80°C and then filtered. The filtrate is sterilized in an ultra-high te...

Embodiment 2

[0048] A preparation method of chrysanthemum formula granules, comprising the steps of:

[0049] a. Select the medicinal materials of chrysanthemum, shake and sieve to remove impurities, and crush them into 0.5cm particles to obtain chrysanthemum decoction pieces;

[0050] b. Moisten the crushed chrysanthemum decoction pieces with 2 times the amount of water, input them into the spiral continuous dynamic countercurrent extractor, add 20 times the amount of hot water at 95°C in reverse and extract continuously for 1 hour, collect the extract, and pass the chrysanthemum medicinal residues through Squeeze and recover part of the medicinal liquid and then discharge it, the recovered part of the medicinal liquid is combined with the extract; the input speed of the chrysanthemum decoction pieces is 100kg / h, and the flow rate of reversely adding hot water is 1000L / h;

[0051] c. The combined extracts are cooled to 50°C and then filtered. The filtrate is sterilized in an ultra-high te...

Embodiment 3

[0055] A preparation method of chrysanthemum formula granules, comprising the steps of:

[0056] a. Select the medicinal materials of chrysanthemum, shake and sieve to remove impurities, and crush them into 0.5cm particles to obtain chrysanthemum decoction pieces;

[0057] b. Moisten the crushed chrysanthemum decoction pieces with 2 times the amount of water, input them into the spiral continuous dynamic countercurrent extractor, add 18 times the amount of 80°C hot water in reverse and extract continuously for 1 hour, collect the extract, and extract the chrysanthemum medicinal residues Part of the medicinal liquid is recovered by extrusion and then discharged, and the recovered partial medicinal liquid is combined with the extract; the input speed of the chrysanthemum decoction pieces is 100kg / h, and the flow rate of reversely adding hot water is 1000L / h;

[0058] c. The combined extracts are cooled to 50°C and then filtered. The filtrate is sterilized in an ultra-high temper...

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Abstract

The invention discloses a preparation method of chrysanthemum formula granules. The preparation method comprises the steps: a, chrysanthemum is crushed or chopped to obtain chrysanthemum decoction pieces; b, the chrysanthemum decoction pieces are continuously input into a continuous dynamic countercurrent extracting machine, hot water is reversely added, continuous dynamic countercurrent extraction is conducted, and an extracting solution is collected; c, the extracting solution is filtered, ultra-high temperature instantaneous sterilization is conducted, and filter liquor is subjected to decompression concentration to be clear paste; d, auxiliary materials are added into the clear paste and dissolved, and spray drying is conducted to obtain dry extract powder; and e, pharmaceutical adjunct is added into the dry extract powder, dry granulating is conducted, and thus the chrysanthemum formula granules are obtained. The preparation method adopts production processes such as continuous countercurrent extracting, ultra-high-temperature instantaneous sterilization, decompression concentration, spray drying and dry granulating, all process parameters are researched, thus the content of active ingredients in the chrysanthemum formula granules can reach the high level continuously and stably, it is ensured that the transfer rate of the active ingredients is consistent with chrysanthemum standard decoction, and the product quality of the chrysanthemum formula granules is improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and in particular relates to a preparation method of chrysanthemum formula granules. Background technique [0002] chrysanthemum Chrysanthemum morifolium The dry flower heads of Ramat., recorded in the 2015 edition of "Chinese Pharmacopoeia", have the functions of dispelling wind and clearing heat, calming the liver and improving eyesight, clearing away heat and detoxifying, and are used for wind-heat and cold, headache, dizziness, red eyes, swelling and pain, dim eyesight, sores Carbuncle swollen poison is a traditional Chinese medicine commonly used in my country. It was first recorded in the "Shen Nong's Materia Medica" in the Eastern Han Dynasty, and it was listed as a top grade. It has a history of more than 2,000 years of application. The main active ingredients of chrysanthemum are chlorogenic acid, luteolin, 3,5- O -Dicaffeoylquinic acid is also an ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/287A61K9/16A61P11/00A61P25/00A61P1/08A61P29/00A61P27/02A61P31/04A61P17/00A61L2/04
CPCA61K9/1623A61K9/1652A61K36/287A61K2236/331A61K2236/51A61L2/0023A61L2202/21A61P1/08A61P11/00A61P17/00A61P25/00A61P27/02A61P29/00A61P31/04
Inventor 张志鹏魏梅程学仁黄瑶林伟雄邓成程汪梅王超马永富蔡盛康
Owner GUANGDONG YIFANG PHARMA
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