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A kind of green preparation method of magnesium glycinate

A technology of magnesium glycinate and glycine, which is applied in the field of preparation of magnesium supplementation preparations, can solve the problems of unstable process, unreacted, waste of raw materials, etc., and achieves the effects of easy operation, simple process and production cost saving.

Active Publication Date: 2022-02-01
河北东华冀衡氨基酸科技有限公司
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Problems solved by technology

[0004] Most of the synthesis and purification of magnesium glycinate in the existing literature are directly reacted with glycine and magnesium compounds, and then the product is obtained through alcohol analysis. However, in the actual reaction process of magnesium glycinate, the solubility of magnesium hydroxide is very small, so that It cannot be well dissolved in the solvent to participate in the reaction. Even if it reacts for a long time, most of the magnesium will not be reacted, and the utilization rate of raw materials is low; at the same time, with the accumulation of the product magnesium glycinate, it will also inhibit the continued reaction of glycine and magnesium hydroxide , causing most of the raw materials to remain unreacted, wasting raw materials
Patent document CN106478438A uses glycine and magnesium compound to react to prepare magnesium glycinate, the yield is 85-97.5%, wherein the yield is 91.8-97.5% when the magnesium compound is magnesium hydroxide, the range is large, and the process is unstable

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  • A kind of green preparation method of magnesium glycinate

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preparation example Construction

[0027] A green preparation method of magnesium glycinate, comprising the following steps:

[0028] A. Add glycine and water to the reaction kettle, heat up to dissolve glycine, wherein water is preferably deionized water, and the mass volume ratio of glycine to water is 0.3-0.6g:1mL, preferably 0.55g:1mL, more preferably 0.5g: 1mL;

[0029] B. Add magnesium hydroxide when the temperature rises to 83-87°C, and remove the insoluble matter by suction filtration after reacting for 2-3 hours to obtain the filtrate; wherein the temperature is preferably raised to 85°C, and magnesium hydroxide is added in 2-3 times, and the reaction time is 2.5h; the molar ratio of glycine and magnesium hydroxide is 2.5-4:1, preferably 3.5:1, more preferably 3:1.

[0030] C. filtrate is down to room temperature, then suction filtration obtains magnesium glycinate wet product and circulation mother liquor;

[0031] D. Vacuum drying the wet product of magnesium glycinate at 105° C. for 2 hours to obt...

Embodiment 1

[0034] Take 500g (6.7mol) of raw material glycine and add 1000mL of deionized water, stir and heat up to 85°C. After the glycine is basically dissolved, add 130g (2.2mol) of magnesium hydroxide measured in two times, react for 2h, filter out insoluble matter, and wait for After the filtrate was cooled to room temperature, suction filtration obtained 320 g of magnesium glycinate wet product, and about 1200 mL of circulating mother liquor. After the wet product of magnesium glycinate is vacuum-dried at 105°C for 2 hours, the dry weight is 290g, wherein the magnesium content is 11.5%, and the magnesium glycinate content is 99.8%, which meets the molecular formula (C 2 h 5 NO 2 ) 2 Mg 2H 2 O content requirements. (In this example, the molar ratio of glycine to magnesium hydroxide is 3.05:1, and the mass volume ratio of glycine to water is 0.5:1g / mL)

Embodiment 2

[0036] Take 120mL of the mother liquor in Example 1, add 33.8g (0.45mol) of glycine, stir and heat up to 83°C, wait until the glycine is basically dissolved, add 13g (0.22mol) of magnesium hydroxide measured in two times, react for 2.5h, and filter out the insoluble After the filtrate is down to room temperature, suction filtration obtains 52g of magnesium glycinate wet product, about 100mL of circulating mother liquor, after 105 ℃ vacuum drying of magnesium glycinate wet product, dry weight is 45.2g, wherein magnesium content is 11.5%, and magnesium glycinate content is 99.8%, yield 98.7%, meet molecular formula (C 2 h 5 NO 2 ) 2 Mg 2H 2 O content requirements. (In this example, the molar ratio of glycine to magnesium hydroxide is 2.84:1, and the mass volume ratio of glycine to water is 0.55:1g / mL)

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Abstract

The invention discloses a green preparation method of magnesium glycinate, which belongs to the technical field of magnesium supplement preparations and comprises the following steps: A. Add glycine and water into the reaction kettle, heat up to dissolve glycine; B. When the temperature rises to 83-87°C, add magnesium hydroxide, react for 2-3 hours, remove insoluble matter by suction filtration, and obtain the filtrate; C. The filtrate is lowered to room temperature, and then suction filtered to obtain a wet product of magnesium glycinate and a circulating mother liquor; D. The magnesium glycinate wet product is vacuum-dried to obtain the final product magnesium glycinate. The invention has a high utilization rate of raw materials, and the prepared magnesium glycinate meets food-grade requirements; and the process flow is simple and easy to operate, environmentally friendly and energy-saving, and is suitable for industrial production.

Description

technical field [0001] The invention relates to the preparation of magnesium supplement preparations, in particular to a preparation method of magnesium glycinate. Background technique [0002] Magnesium is one of the most abundant cations in human cells. It is also an important substance that regulates the balance of calcium, sodium, and potassium ions inside and outside cells. It is an essential mineral element for the human body. Magnesium can be used clinically to prevent the occurrence of atherosclerosis, prevent arrhythmia and heart failure, myocardial infarction, reduce the incidence of cancer, etc., and as an adjuvant therapy drug. Magnesium resists oxidative stress by regulating the secretion of certain hormones and plays an anti-lipid oxidation role. Organic magnesium can also reduce the content of adrenal hormones in plasma. [0003] At present, most of the magnesium supplement drugs used by the human body are inorganic salts, which are not easy to absorb, and co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C227/18C07C229/08
CPCC07C227/18C07C229/08
Inventor 王秀茹马宁宁卢淑婷宋铁犇曾著飞王立辉韩素娟刘辉翟学昌曲艳敏
Owner 河北东华冀衡氨基酸科技有限公司
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