A kind of small molecular toxin with insect selective activity and its application

A small-molecule, selective technology that is applied in applications, pesticides, organic chemistry, etc., to achieve strong effects and reliable results

Active Publication Date: 2022-04-15
HUNAN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time, there is no report on the selective effect of these acetylpolyamine small molecules on insect sodium channels

Method used

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  • A kind of small molecular toxin with insect selective activity and its application
  • A kind of small molecular toxin with insect selective activity and its application
  • A kind of small molecular toxin with insect selective activity and its application

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Embodiment Construction

[0029] The present invention provides a small molecule toxin with insect selective activity, the small molecule toxin with insect selective activity is a quaternary ammonium small molecule toxin separated and purified from the crude venom of Arachnid grandis, and the relative molecular weight is 758.4934 , NMR structure analysis The molecular formula of the small molecule toxin with insect selective activity is C 36 h 63 o 6 N 12 , whose structural formula is:

[0030]

[0031] The application of a small-molecule toxin with insect selective activity in insecticides or in neurobiological reagents and / or medicines provided by the present invention is especially used as a method of blocking or completely blocking insect sodium ion channels. application of pesticides. When the small molecule toxin with insect selective activity completely blocks the insect sodium ion channel, the concentration of the small molecule toxin with insect selective activity is not more than 10 μm...

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Abstract

The invention belongs to the technical field of chemistry and chemical engineering, and relates to a small molecule toxin with insect selective activity and its application. The small molecule toxin with insect selective activity isolated and purified from the crude venom of E. magna is a quaternary ammonium small molecule toxin , the relative molecular weight is 758.4934, and the molecular formula of this small molecule toxin with insect selective activity is C 36 h 63 o 6 N 12 , the present invention provides a small molecule toxin with selective activity on insects, which is isolated and purified from the crude venom of Arachnid grandis, which is less affected by pH, has a stronger effect and is more stable, and its application .

Description

technical field [0001] The invention belongs to the technical field of chemistry and chemical engineering, and relates to a small molecule toxin and its application, in particular to a small molecule toxin with insect selective activity and its application. Background technique [0002] The large-bellied garden spider (Araneus ventricosus) is a medium-sized spider that feeds on insects, and belongs to the phylum Arthropoda, Araneus, Aranea, Orbidae, and Orb genus in classification. The arachnid is one of the most widely distributed spiders in the world, and its venom contains a large number of toxic components that can anesthetize or kill insects. Explore the structural and functional characteristics of these insect-specific small-molecule toxins isolated and purified from the crude venom of E. grandis, and screen out precursor molecules that may be used as neurobiological research tool reagents, drugs and insecticides. At present, there are very few studies on the venom of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D209/18A01N47/44A01P7/04
Inventor 段志贵刘凯
Owner HUNAN NORMAL UNIVERSITY
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