Pharmaceutical composition containing pimavanserin tartrate

A technology of pimavanserin and tartaric acid, which is applied in the field of preparation of pharmaceutical compositions and tablets, can solve the problems of irritation and poor compliance, and achieve complete dissolution, fast absorption, and good product stability

Inactive Publication Date: 2019-07-02
DANYANG ZHENGYUAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, because pimavanserin tartrate tastes bitter and has a pungent taste, its compliance is poor

Method used

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  • Pharmaceutical composition containing pimavanserin tartrate
  • Pharmaceutical composition containing pimavanserin tartrate
  • Pharmaceutical composition containing pimavanserin tartrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] prescription

[0061]

[0062] Preparation

[0063] 1) Pulverize β-cyclodextrin, pimavanserin tartrate, and low-substituted hydroxypropyl cellulose, stir evenly, pass through a 50-mesh sieve, and set aside;

[0064] 2) Pass lactose, low-substituted hydroxypropyl cellulose, micropowder silica gel, talcum powder, and magnesium stearate through a 50-mesh sieve respectively, and set aside;

[0065] 3) Mix the pimavanserin tartrate granules prepared in 1) evenly with the auxiliary materials in 2), add copovidone, stir evenly, and press into tablets to obtain the product.

Embodiment 2

[0067] prescription

[0068]

[0069] Preparation

[0070] 1) Pulverize β-cyclodextrin, pimavanserin tartrate, and cross-linked polyvinylpyrrolidone, stir evenly, pass through a 60-mesh sieve, and set aside;

[0071] 2) Cross-linked polyvinylpyrrolidone and talcum powder are passed through a 60-mesh sieve respectively, and set aside;

[0072] 3) Mix the pimavanserin tartrate granules prepared in 1) evenly with the auxiliary materials in 2), add copovidone, stir evenly, and press into tablets to obtain the product.

Embodiment 3

[0074] prescription

[0075]

[0076] Preparation

[0077] 1) Pulverize β-cyclodextrin, pimavanserin tartrate, and low-substituted hydroxypropyl cellulose, stir evenly, pass through an 80-mesh sieve, and set aside;

[0078] 2) Pass low-substituted hydroxypropyl cellulose and micropowder silica gel through an 80-mesh sieve respectively, and set aside;

[0079] 3) Mix the pimavanserin tartrate granules prepared in 1) evenly with the auxiliary materials in 2), add copovidone, stir evenly, and press into tablets to obtain the product.

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PUM

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Abstract

The invention belongs to the pharmaceutical technical field, and in particular, relates to a pharmaceutical composition containing pimavanserin tartrate; the pharmaceutical composition comprises pimavanserin tartrate, a filling agent, a disintegrator and a lubricant, and is characterized by also comprising povidone and beta-cyclodextrin. The product has good stability, bitterness covering, good taste, fast absorption, and better product quality; the product is simple and feasible to produce and operate, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition containing pimavanserin tartrate and a preparation method of tablets thereof. Background technique [0002] Pimavanserin tartrate (pimavanserin) is used for the treatment of atypical antipsychotics. It exists as pimavanserin tartrate, and its chemical name is marserin hemitartrate; 1-(4-fluorobenzyl)-3 -(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)urea: tartrate (2:1), molecular weight 1005.20 (tartrate), molecular formula (C 25 h 34 FN 3 o 2 ) 2 ·C 4 h 6 o 6 , the chemical structural formula is: [0003] [0004] The pharmaceutical composition containing pimavanserin tartrate, after wet granulation, was incompletely dissolved in the prescribed 60 minutes in the in vitro dissolution test, that is, under the prescribed taking method conditions, it could not fully meet the requirements of the human body. Stable drug concentrat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/32A61K47/40A61K31/4468A61P25/18
CPCA61K9/2027A61K9/205A61K31/4468
Inventor 徐艳红
Owner DANYANG ZHENGYUAN BIOTECH
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