A strain of Pseudomonas aeruginosa phage and its application

Abstract

The present invention relates to a pseudomonas aeruginosa phage and an application thereof, and particularly discloses the phage capable of entering blood and the application thereof. The phage singlebody is the pseudomonas aeruginosa phage with a Latin name P. Aeruginosaphage, and named as ASP11, and has a broad-spectrum bactericidal ability against pseudomonas aeruginosa. The phage ASP11 is preserved in China General Microbiological Culture Collection Center, a preservation date is September 26, 2018 and a preservation number is CGMCC NO.16395. Both in vivo and in vitro tests show that thephage has a strong cleavage effect on the pseudomonas aeruginosa and provides an effective method for prevention and treatment of pseudomonas aeruginosa infected diseases.

Description

technical field

[0001] The invention belongs to the field of biotechnology, and in particular relates to a phage isolate capable of specifically lysing Pseudomonas aeruginosa strains and an application thereof. Background technique

[0002] Mink hemorrhagic pneumonia is an acute infectious disease caused by Pseudomonas aeruginosa. It has a rapid onset and is difficult to control. It was endemic in many countries and regions, resulting in the death of a large number of minks and serious economic losses. Pseudomonas aeruginosa has a variety of natural and acquired mechanisms to resist a variety of antibiotics. These mechanisms include efflux pumps, antibiotic degradation, modification of enzyme systems, and the function of reducing membrane permeability. Many strains of Pseudomonas aeruginosa that are drug resistant and clinically isolated show simultaneous resistance to multiple antibiotics. Meat feed contaminated with Pseudomonas aeruginosa, feces, urine, secretions of infe...

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