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Microfluidic device and making method, biomolecular quantity detection method and system

A technology of microfluidics and devices, applied in chemical instruments and methods, instruments, analytical materials, etc., can solve the problems of inconvenient long-term maintenance, reduced device portability/use convenience, high cost of testing equipment, etc., to achieve The effect of low test cost, convenient disassembly and maintenance, high portability and practicability

Active Publication Date: 2019-09-13
BOE TECH GRP CO LTD +1
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, after the calibration of common microfluidic devices is completed, optical testing is usually used for quantitative characterization, which requires large-scale equipment such as

Method used

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  • Microfluidic device and making method, biomolecular quantity detection method and system
  • Microfluidic device and making method, biomolecular quantity detection method and system
  • Microfluidic device and making method, biomolecular quantity detection method and system

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[0061] In order to explain the present invention more clearly, the present invention will be further described below in conjunction with preferred embodiments and drawings. Similar components in the drawings are denoted by the same reference numerals. Those skilled in the art should understand that the content described below is illustrative rather than restrictive, and should not limit the protection scope of the present invention.

[0062] Such as figure 1 Shown are a top view of a microfluidic device structure disclosed in an embodiment of the present invention and a corresponding front cross-sectional view (the top diagram is a top view, and the bottom diagram is a front cross-sectional view corresponding to the position), including

[0063] Glass substrate (not shown in the figure);

[0064] A plurality of first metal strips 1 arranged on the glass substrate and arranged along the first direction;

[0065] The photoresist body 2 extending along the first direction covers the plu...

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Abstract

The invention discloses a microfluidic device and a making method, a biomolecular quantity detection method and system. The microfluidic device includes: a glass substrate; a plurality of first metalstrips formed on the glass substrate; a photoetching colloid covering the plurality of first metal strips; a flow channel cavity formed in the photoetching colloid; and a plurality of second metal strips formed on the photoetching colloid, wherein the head and tail ends of the first metal strips are in electric connection with the head and tail ends of the adjacent second metal strips, so that theplurality of first metal strips and second metal strips form an air core inductance structure around the flow channel cavity. According to the invention, target molecules are captured by modified antigen/antibody in the air core inductance cavity, and the antigen/antibody molecules of modified magnetic particles are utilized for labeling, the quantity of target molecules is measured through the inductance value change caused by the magnetic particles carried by the antigen/antibody in the inductance cavity, fluorescence microscope and other large equipment are not needed, the microfluidic device has high portability and practicability, is low in test cost, and is convenient for disassembly and maintenance.

Description

technical field [0001] The invention relates to the field of biological detection. More specifically, it relates to a microfluidic device and a manufacturing method, a method and a system for detecting the quantity of biomolecules. Background technique [0002] The use of microfluidic devices to analyze the quantity / concentration of biological target molecules has become a common analysis method in modern medicine. However, after the calibration of common microfluidic devices is completed, optical testing is usually used for quantitative characterization, which requires large-scale equipment such as fluorescence microscopes, resulting in reduced device portability / convenience of use, and at the same time, the cost of testing equipment remains high. Not easy for long-term maintenance. Contents of the invention [0003] The purpose of the present invention is to provide a microfluidic device and its manufacturing method, biomolecular quantity detection method and system, a...

Claims

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Application Information

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IPC IPC(8): B01L3/00G01N15/10
CPCB01L3/502707G01N15/10G01N2015/1006G01N15/1056G01N15/1031G01N33/54373G01N33/588G01N27/026B01L2200/12B01L2300/08B01L2300/12G01N15/0656G03F7/2022G03F7/26
Inventor 孙拓
Owner BOE TECH GRP CO LTD
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