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Quality detection method of decotion of poria cocos, cassia twig, atractylodes macrocephala koidz and liquorice

A quality detection method, the technology of Lingguizhu, is applied in the field of quality detection of Lingguizhugan Decoction, achieving the effect of high precision, good reproducibility and good stability

Active Publication Date: 2019-11-12
NANJING HAICHANG CHINESE MEDICINE GRPCO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology helps researchers identify better ways for extracts from Chinese herbs called Liuqianhuanshan (LINGGUAN) without losing their effectiveness or affecting them' healthy properties during extractions. It also includes various methods like gradual release programs with different compositional profiles, flow rates, light sources, columns, temperatures, and other factors such as pH levels. These technical results help improve understanding on how well-behaved medications are being extracted from traditional medicine.

Problems solved by technology

Technical Problem: The technical problem addressed in this patented text relates to improving the accuracy and reliability of detecting different chemical components contained within lininggGuize Plants' extract called lysergan or licourine during manufacturing processes like drug development.

Method used

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  • Quality detection method of decotion of poria cocos, cassia twig, atractylodes macrocephala koidz and liquorice
  • Quality detection method of decotion of poria cocos, cassia twig, atractylodes macrocephala koidz and liquorice
  • Quality detection method of decotion of poria cocos, cassia twig, atractylodes macrocephala koidz and liquorice

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Experimental program
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Effect test

Embodiment 1

[0049] A quality detection method of Linggui Zhugan Decoction, comprising the following steps:

[0050] Step 1, the preparation of Linggui Zhugan Decoction test solution:

[0051] Taking the medicinal materials in Table 1, weigh 60g of Poria cocos, 45g of cassia twig, 45g of Atractylodes macrocephala, and 30g of licorice, put them in a decoction pot, add 6 times the amount of water, decoct and extract for 2 hours, filter, concentrate under reduced pressure, and add an appropriate amount of methanol Dissolve to constant volume, and pass through a 0.45 μm microporous membrane to obtain 10 batches of the test solution.

[0052] Step 2, preparation of mixed reference substance solution:

[0053] Accurately weigh the reference substances of liquiritin, cinnamic acid, ammonium glycyrrhizinate and atractylodes lactone Ⅰ, place them in a volumetric flask, dilute to the mark with methanol, and shake well to make concentrations of 1.17mg / mL and 1.15mg / mL respectively , 1.61mg / mL and 0.9...

Embodiment 2

[0068] Embodiment 2 methodological investigation

[0069] 1. Precision

[0070] Select the test solution prepared in Example 1, inject 6 times continuously, record the relative retention time and relative peak area of ​​the four components at the corresponding detection wavelength, and calculate the RSD of the relative retention time and relative peak area. The instrument precision data are shown in Table 4.

[0071] Table 4 precision data

[0072]

[0073] Results The RSDs of the relative retention time and relative peak area of ​​each component were less than 5%, indicating that the precision of the instrument was good.

[0074] 2. Repeatability

[0075] Get 6 parts of the test sample prepared in Example 1, inject and detect by the chromatographic conditions of Example 1, record the relative retention time and relative peak area of ​​the four components, and calculate the RSD of the relative retention time and relative peak area. The repeatability data of the four com...

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Abstract

The invention discloses a quality detection method of decotion of poria cocos, cassia twig, atractylodes macrocephala koidz and liquorice. The method comprises the following steps: step 1, preparationof a sample solution of the decotion of poria cocos, cassia twig, atractylodes macrocephala koidz and liquorice; step 2, preparation of a mixed reference solution; step 3, establishment of a linear regression equation; and step 4, content measurement. In the quality detection method disclosed by the invention, according to the structural features of active ingredients contained in the decotion ofporia cocos, cassia twig, atractylodes macrocephala koidz and liquorice, the optimal mobile phase composition, a gradient elution program, a flow rate, a detection wavelength, a chromatographic column, a column temperature and other analysis conditions are screened by a large number of experiments, and it has been proved by many experiments that the quality detection method of decotion of poria cocos, cassia twig, atractylodes macrocephala koidz and liquorice provided by the invention can be used for detecting and evaluating the quality of the decotion of poria cocos, cassia twig, atractylodes macrocephala koidz and liquorice relatively comprehensively, objectively and accurately, and is of great significance for ensuring the clinical efficacy of the decotion.

Description

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Claims

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Application Information

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Owner NANJING HAICHANG CHINESE MEDICINE GRPCO LTD
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