A kind of rehmannia yinzi pharmaceutical composition, preparation method and detection method

Abstract

The invention relates to a medicinal composition of Rehmannia glutinosa, a preparation method and a detection method thereof. The medicinal composition is composed of the following formulas: 0.5-1.5 parts of rehmannia glutinosa, 0.5-1.5 parts of Morinda officinalis meat, and 0.5-1.5 parts of cornus , Dendrobium 0.5-1.5 parts, Cistanche 0.5-1.5 parts, Paofu Tablets 0.5-1.5 parts, Schisandra 0.5-1.5 parts, cinnamon 0.5-1.5 parts, Poria cocos 0.5-1.5 parts, Ophiopogon japonicus 0.5-1.5 parts, Shichangpu 0.5 to 1.5 parts, 0.5 to 1.5 parts of polygala, 4 to 6 parts of ginger, 3 to 6 parts of jujube, and 0.5 to 1.5 parts of peppermint. The invention is prepared by water extraction, freeze drying and other methods. Technical decompression drying leads to the loss of morroniside, loganin and schisandrin A, and the state of dry paste powder is granular, which is a relatively hard technical problem; the present invention has determined the specific detection methods of qualitative identification, fingerprints, and content determination. A good detection method can effectively reflect the quality of the material reference quality, and solve the technical problem that the existing technical quality detection methods are difficult to reflect the quality of the material reference quality.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a rehmannia root medicinal composition, a preparation method and a detection method. Background technique [0002] Dihuang Yinzi is the 53rd prescription in the "Catalogue of Ancient Classical Prescriptions" (the first batch) released by the State Administration of Traditional Chinese Medicine in April 2018. Dihuang Yinzi comes from Jin Liu Wansu's "Huang Di Su Wen Xuan Ming Lun Fang". The original text of the prescription is: cooked and dried rehmannia glutinosa, Morinda officinalis (heart removed), dogwood, dendrobium, Cistanche deserticola (soaked in wine, roasted), aconite (cannon), schisandra, laurel, white poria cocos, Ophiopogon japonicus (heart removed), calamus, Polygala (heart removed) is divided into equal parts. The right is the end, three qian per serving, one and a half cups of water, five slices of ginger, one jujube, and mint, all fried together until eight minutes apart...

AI Technical Summary

Problems solved by technology

[0003] Dihuang Yinzi has a certain curative effect, but has the following defects: ①Since the decoction end point in the original prescription is described as "decoction to eight points", according to the textual research results, it is "eight points" of the liquid level, but the height of the extract is used as the decoction height. At the end of cooking, it is necessary to measure the height of the extract in real time during the test, which requires a long time away from the fire source to operate, resulting in discontinuous cooking. Under the condition of fixed heating (open flame) and controlled firepower, the height of the extract can be used Correlation with the decoction time, the time point at which the decoction end extract liquid reaches the "eighth" height is taken as the decoction time

②Since Dihuang Yinzi is a boiled powder, the original text is taken without dregs, so there are drug residues and sediment

③The mass ratio of the concentrated feed amount to the concentrated liquid was not specified, resulting in foaming and non-melting in the dry powder state, and the powder was not loose. ④The concentration temperature was not specified, and the wall was formed during the concentration process, the total amount of morroniside and loganin extracted, and schisandrin The total amount of A extraction is affected, and the concentration efficiency is low

⑥ It is only clarified that Rehmannia glutinosa should be pulverized, but it is not clarified whether it should be pulverized into coarse powder or fine powder, so it is difficult to operate during pretreatment

⑦Existing quality testing methods are difficult to reflect the quality of the material reference quality

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