Rehmannia decoction pharmaceutical composition and preparation method thereof, and detection method

Abstract

The invention relates to a rehmannia decoction pharmaceutical composition and a preparation method thereof, and a detection method. The pharmaceutical composition consists of the following formula: 0.5-1.5 parts of prepared rehmannia roots, 0.5-1.5 parts of Morinda pulp, 0.5-1.5 parts of cornus officinalis pulp, 0.5-1.5 parts of dendrobium, 0.5-1.5 parts of wine-processed cistanche, 0.5-1.5 partsof prepared common monkshood branched roots, 0.5-1.5 parts of Chinese magnoliavine fruits, 0.5-1.5 parts of cinnamon, 0.5-1.5 parts of poria cocos, 0.5-1.5 parts of dwarf lilyturf tuber, 0.5-1.5 partsof rhizoma acori graminei, 0.5-1.5 parts of milkwort root, 4-6 parts of raw ginger, 3-6 parts of Chinese dates and 0.5-1.5 parts of mint. The composition is prepared by a method including water extraction, freeze drying and the like. The process solves the technical problems that in the prior art, morroniside, loganin and schisandrin are lost due to reduced-pressure drying, and the dry paste powder is granular and hard. The invention determines a specific detection method for qualitative identification, fingerprint spectrum and content determination. The good detection method effectively reflects the advantages and disadvantages of the material reference mass and solves the technical problem that quality detection methods in the prior art are difficult to reflect the advantages and disadvantages of the material reference mass.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a rehmannia root medicinal composition, a preparation method and a detection method. Background technique [0002] Dihuang Yinzi is the 53rd prescription in the "Catalogue of Ancient Classical Prescriptions" (the first batch) released by the State Administration of Traditional Chinese Medicine in April 2018. Dihuang Yinzi comes from Jin Liu Wansu's "Huang Di Su Wen Xuan Ming Lun Fang". The original text of the prescription is: cooked and dried rehmannia glutinosa, Morinda officinalis (heart removed), dogwood, dendrobium, Cistanche deserticola (soaked in wine, roasted), aconite (cannon), schisandra, laurel, white poria cocos, Ophiopogon japonicus (heart removed), calamus, Polygala (heart removed) is divided into equal parts. The right is the end, three qian per serving, one and a half cups of water, five slices of ginger, one jujube, and mint, all fried together until eight minutes apart...

AI Technical Summary

Problems solved by technology

[0003] Dihuang Yinzi has a certain curative effect, but has the following defects: ①Since the decoction end point in the original prescription is described as "decoction to eight points", according to the textual research results, it is "eight points" of the liquid level, but the height of the extract is used as the decoction height. At the end of cooking, it is necessary to measure the height of the extract in real time during the test, which requires a long time away from the fire source to operate, resulting in discontinuous cooking. Under the condition of fixed heating (open flame) and controlled firepower, the height of the extract can be used Correlation with the decoction time, the time point at which the decoction end extract liquid reaches the "eighth" height is taken as the decoction time

②Since Dihuang Yinzi is a boiled powder, the original text is taken without dregs, so there are drug residues and sediment

③The mass ratio of the concentrated feed amount to the concentrated liquid was not specified, resulting in foaming and non-melting in the dry powder state, and the powder was not loose. ④The concentration temperature was not specified, and the wall was formed during the concentration process, the total amount of morroniside and loganin extracted, and schisandrin The total amount of A extraction is affected, and the concentration efficiency is low

⑥ It is only clarified that Rehmannia glutinosa should be pulverized, but it is not clarified whether it should be pulverized into coarse powder or fine powder, so it is difficult to operate during pretreatment

⑦Existing quality testing methods are difficult to reflect the quality of the material reference quality

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