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A kind of triterpenoid compound and its pharmaceutically acceptable salt, preparation method and application

A technology for compounds and triterpenes, applied in the fields of triterpenoids and their pharmaceutically acceptable salts and preparations, can solve the problems of enhancement, unclear active ingredients, rising drug costs, etc., and achieves good anti-inflammatory effect and novel structure , good antibacterial effect

Active Publication Date: 2022-06-07
ZHUZHOU QIANJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Rosa radix has significant medicinal value, but so far its active ingredients are still unclear, and there are few studies on the efficacy of its monomeric compounds
However, in the process of application of Chinese herbal medicine extracts, due to its complex components, in order to achieve therapeutic effects, it will inevitably lead to an increase in the amount of use. cause or enhance side effects

Method used

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  • A kind of triterpenoid compound and its pharmaceutically acceptable salt, preparation method and application
  • A kind of triterpenoid compound and its pharmaceutically acceptable salt, preparation method and application
  • A kind of triterpenoid compound and its pharmaceutically acceptable salt, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1 Extraction and separation of compound 2α, 3α, 19α, 22α-tetrahydroxy-12-ene-28-carboxylic acid

[0054] Taking golden cherry root as the research object, its 70% ethanol extract was extracted and separated, in order to clarify its specific activity cost and biological activity of different components. The specific medicinal material of golden cherry root was provided by Zhuzhou Qianjin Industry Co., Ltd., and was identified as the root of Rosa laevigata Michx.

[0055] The instruments used in the extraction and separation process include: Dionex U-3000 high performance liquid chromatograph; WatersAcquity UPLC / Xevo G2 QTOF system; FW135 pulverizer; Bruker Ascend 600M superconducting nuclear magnetic resonance instrument; Ultimate 3000 ultra-high performance liquid chromatograph and LTQ Orbitray Velos pro Mass Spectrometer; LC 3000 Preparative Liquid Chromatograph; BUCHI Medium Pressure Preparative Chromatography BUCHI flash systems X-10 flash column system.

...

Embodiment 2

[0062] Compound 2α, 3α, 19α, 22α-tetrahydroxy-12-ene-28-carboxylic acid During the extraction process, the crude powder of Radix chinensis can also be refluxed for 3 times with 50% ethanol, refluxed for 1 hour each time, and concentrated under reduced pressure , to obtain a dry paste; then according to the extraction and separation process described in Example 1, the target compound was obtained.

Embodiment 3

[0064] Compound 2α, 3α, 19α, 22α-tetrahydroxy-12-ene-28-carboxylic acid During the extraction process, the crude powder of Radix chinensis can also be refluxed for 3 times with 100% ethanol, refluxing for 1 hour each time, and concentrated under reduced pressure. , to obtain a dry paste; then according to the extraction and separation process described in Example 1, the target compound was obtained.

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Abstract

The invention discloses a triterpenoid compound, a pharmaceutically acceptable salt thereof, a preparation method and an application thereof. The structural formula of the compound is shown in formula I, and the structure of the pharmaceutically acceptable salt is shown in formula II; wherein M is an alkali metal ion, an alkaline earth metal ion or an ammonium radical. The compound of the present invention has a novel structure, is originally derived from the root of Rosa rosa, and is isolated from the root extract of Rosa rosa, and has good antibacterial effect against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Candida albicans, At the same time, it also has good anti-inflammatory effect, analgesic effect, and antipyretic effect, and can be prepared as antibacterial drugs, anti-inflammatory drugs, analgesic drugs or antipyretic drugs for application; Equivalent or identical biological activity.

Description

technical field [0001] The present invention relates to the technical field of medicinal chemistry, and more particularly, to a triterpenoid compound and a pharmaceutically acceptable salt thereof, as well as a preparation method and application thereof. Background technique [0002] Golden cherry root, also known as Golden Cherry Blossom, Tuogu Dan, etc., is the root of the dicotyledonous Rosaceae plant Golden Cherry Blossom Rosaevigata Michx. , stop diarrhea, blood and vaginal discharge." Its taste is bitter, sour, astringent, and flat. Returns to the spleen, liver and kidney meridians, and has the functions of clearing away heat and removing dampness, detoxifying and reducing swelling, promoting blood circulation and stopping bleeding, and astringent and astringent. Golden cherry root mainly contains triterpenes, flavonoids, and tannins, which can treat nocturnal emission, enuresis, dysentery and diarrhea, metrorrhagia, uterine prolapse, hemorrhoids, burns, etc. Common...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J63/00A61K31/56A61P31/04A61P31/10A61P29/00A61P15/02A61P15/00
CPCC07J63/008A61P31/04A61P31/10A61P29/00A61P15/02A61P15/00Y02A50/30
Inventor 龚云白璐彭开锋凌勇根张鹏李春廖端芳
Owner ZHUZHOU QIANJIN PHARMA
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