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Application of Erzhi formula compound in preparation of drug for preventing and treating BPH

A compound and drug technology, applied in the field of preparation of drugs for the prevention and treatment of benign prostatic hyperplasia, can solve problems such as cardiovascular complications, sexual dysfunction, adverse reactions in patients with BPH, accompanying pain, nausea and vomiting, etc.

Inactive Publication Date: 2020-01-14
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the clinically used drugs (western medicines) are designed around the pathogenesis of BPH, mainly summarized as 5α-reductase inhibitors, α1-adrenoceptor blockers, anti-estrogens, androgen drugs, etc., with ingredients The advantages of single and clear target, but long-term use will bring different degrees of adverse reactions to BPH patients. Mild cases are accompanied by symptoms such as pain, nausea and vomiting, and severe cases may cause cardiovascular complications, sexual dysfunction, etc. [4] , still needs to be further improved, so the application of traditional Chinese medicine in the treatment of BPH has become a hot spot in current research

Method used

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  • Application of Erzhi formula compound in preparation of drug for preventing and treating BPH
  • Application of Erzhi formula compound in preparation of drug for preventing and treating BPH
  • Application of Erzhi formula compound in preparation of drug for preventing and treating BPH

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0114] Example 1: Study on the chemical components of Erzhi Recipe in inhibiting the proliferation of human prostate hyperplasia epithelial cells

[0115] 1. Materials and methods

[0116] 1.1 Main instruments

[0117] As shown in Table 1 below.

[0118] Table 1: Main instruments

[0119]

[0120] 1.2 Main reagents

[0121] As shown in Table 2 below.

[0122] Table 2: Main reagents

[0123]

[0124]

[0125] 1.3 The compounds derived from Ligustrum lucidum and Eclipta prostrata are shown in Table 3

[0126] Table 3: Compounds from Ligustrum lucidum and Eclipta prostrata

[0127]

[0128]

[0129]

[0130]

[0131] 1.4 Preparation of the main solution

[0132] 1.4.1 Preparation of mother liquor of each compound derived from Ligustrum lucidum and Eclipta prostrata

[0133] Weigh various compounds with a one-hundred-thousandth balance, add DMSO to dissolve them to a concentration of 100 mM according to their weighed amount and relative molecular mass, and store in aliquots at -20°C.

[0134] 1.4....

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PUM

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Abstract

The invention belongs to the field of traditional Chinese medicines, and relates to an application of an Erzhi formula compound in preparation of a drug for preventing and treating benign prostatic hyperplasia (BPH). Specifically, the invention relates to an application of a compound in preparation of a medicine selected from the following medicines: (1) a medicine for treating and / or preventing benign prostatic hyperplasia; (2) a medicine for inhibiting proliferation of human prostatic hyperplasia epithelial cells; or (3) a drug for inhibiting PCNA protein expression and / or inhibiting mRNA expression; wherein the compound is selected from dammarendiol, p-hydroxyphenylethanol, ligustrosidic acid, verbascoside, oleoside methyl ester, luteolin, ABiochanin A, echinocystic acid and echinocystic acid-28-O-beta-D-glucose. The Erzhi formula compound or a combination of the Erzhi formula compound is effective in the treatment and / or prevention of benign prostatic hyperplasia.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to the use of Erzhifang compounds in the preparation of drugs for preventing and treating benign prostatic hyperplasia (BPH). Background technique [0002] Benign prostatic hyperplasia (BPH) is a common and frequently-occurring disease in middle-aged and elderly men. Epidemiological studies have shown that with age, the incidence of BPH increases year by year, and the probability of BPH in men around 50 About 50%, the probability of BPH for men 80 years and older is as high as 85% [1] . With the rapid development of my country's economy and the increasing aging of the population, diseases closely related to age growth have received more and more attention, and BPH is among them. The main clinical manifestations of BPH include frequent urination, urgency, dysuria, etc., accompanied by bladder obstruction and lower urinary tract symptoms. More severe cases can cause urinary tract...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61K31/56A61K31/192A61K31/05A61K31/352A61K31/7032A61K31/7048A61K31/235A61K31/381A61K31/7024A61P13/08
CPCA61K31/575A61K31/56A61K31/192A61K31/05A61K31/352A61K31/7032A61K31/7048A61K31/235A61K31/381A61K31/7024A61P13/08A61K36/638A61K36/28
Inventor 高秀梅陶蕊苗琳毛浩萍刘二伟韩立峰杨文志陈璐
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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