A short peptide that promotes nuclear translocation of tfeb and a linear short peptide based on it and its application in alleviating cerebral ischemic injury

A short peptide, translocation technology, applied in the field of biomedicine, can solve problems such as no research reports

Active Publication Date: 2021-04-30
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Whether regulating CMA is the key to alleviating cerebral ischemic injury, and whether TFEB, a key regulator of the autophagy-lysosome pathway, can regulate CMA to alleviate cerebral ischemic injury, after searching, it was found that there is no research report in this regard

Method used

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  • A short peptide that promotes nuclear translocation of tfeb and a linear short peptide based on it and its application in alleviating cerebral ischemic injury
  • A short peptide that promotes nuclear translocation of tfeb and a linear short peptide based on it and its application in alleviating cerebral ischemic injury
  • A short peptide that promotes nuclear translocation of tfeb and a linear short peptide based on it and its application in alleviating cerebral ischemic injury

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Embodiment Construction

[0031] In order to enable those skilled in the art to better understand the solutions of the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only It is an embodiment of a part of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0032] It should be noted that the terms "first" and "second" in the description and claims of the present invention and the above drawings are used to distinguish similar objects, but not necessarily used to describe a specific sequence or sequence. It is to be understood that the data so used are interchangeable under appropriate ...

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Abstract

The invention discloses a short peptide for promoting nuclear translocation of TFEB, a linear short peptide based on the short peptide and its application for alleviating cerebral ischemic injury, and belongs to the technical field of biomedicine. The short peptide disclosed in the present invention is a short peptide fused with the functional region of TFEB protein and 14-3-3 protein, and its nucleotide sequence is shown in SEQ.ID.NO.1. The invention also discloses a linear short peptide protecting the above short peptide, which is formed by fusion of a membrane-penetrating peptide and the above short peptide. The present invention verifies through experiments that the synthesized fusion peptide can regulate TFEB nuclear translocation, promote CMA and reduce cell damage. Therefore, its application as a new therapeutic target for alleviating neuron death and improving cerebral ischemic injury is disclosed.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to a short peptide that promotes TFEB nuclear translocation, enhances chaperone-mediated autophagy (CMA) and relieves nerve damage and its application, and specifically relates to a method for promoting TFEB nuclear translocation Short peptides and linear short peptides based on them and their application in alleviating cerebral ischemic injury. Background technique [0002] Stroke is a serious threat to human life and health. There are approximately 16.9 million new stroke patients worldwide each year, and 5.9 million patients die of stroke-related diseases; another 33 million stroke patients need long-term treatment and care, which brings heavy burdens to society and families. Burden (Lancet, 2017). tPA (Tissue plasminogen activator) is currently the only drug approved by the US FDA for the treatment of ischemic stroke, but its treatment time window is short and increases the r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K19/00A61K38/08A61K47/64A61P9/10A61P25/00
CPCA61K38/00A61P9/10A61P25/00C07K7/06C07K2319/10
Inventor 方宗平冯云侯武刚张西京熊利泽董海龙苏斌虓李雨衡王佳佳王世全王进邓姣杨博左文强
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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