Preparation system and preparation method of Al<18>F-PSMA-BCH

Abstract

The invention relates to the technical field of medicinal chemistry, and provides a preparation system and a preparation method of Al18F-PSMA-BCH. The preparation system comprises a first flushing unit, an anion exchange column, a fluorination reaction bottle and a purification unit, wherein the first flushing unit is communicated with the anion exchange column; the anion exchange column is communicated with the fluorination reaction bottle through a first pipeline; the fluorination reaction bottle is loaded with an aqueous solution containing a precursor compound, AlCl3 and a pH buffer agent;the fluorination reaction bottle outputs the produced aqueous Al18F-PSMA-BCH solution through a second pipeline; and a purification unit is installed on the second pipeline. According to the invention, 18F<-> in a target aqueous solution is captured through the anion exchange column, and free 18F<-> in the produced aqueous solution output through a reaction is removed through the purification unit, so the yield and the specific activity of a labeled product are improved, the purity of the obtained produced aqueous solution is high, and the influence of the free 18F<-> on the diagnosis resultof a patient is correspondingly reduced.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to an Al 18 Preparation system and preparation method of F-PSMA-BCH. Background technique [0002] At present, prostate cancer is one of the important diseases threatening men's health. In my country, the incidence of prostate cancer is increasing year by year, and most patients are diagnosed with advanced prostate cancer. Early diagnosis and early treatment have always been an important means to improve the cure rate of tumors and the survival rate of patients. [0003] Prostate-specific membrane antigen (PSMA) is specifically highly expressed in prostate cancer and its metastatic cells, and is significantly related to the malignancy of the tumor. In recent years, small molecule probes targeting PSMA have been extensively studied, among which 68 Ga and 18 F-labeled molecular probes were predominant. compared to 68 For Ga, 18 F has its unique advantages, such as ...

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Problems solved by technology

However, relatively 68 Ga-labeled, conventional 18 The F labeling method has disadvantages such as long labeling time, high reaction temperature, strict anhydrous requirements, and low labeling rate.

[0004] As described in the patent application number 201710368982.3 "Al 18 F-labeled PSMA targeting inhibitor and its preparation method and application", Al 18 The marking of F-PSMA-BCH mainly adopts the method of manual marking, because 18 The output of F manual labeling is limited, and the concentration has a great influence on the labeling rate. During the labeling process, a large number of carrier-free samples are usually loaded and washed. 18 F-, and actually in the marking process, only need to use one-fourth to one-fifth of the amount, so that in the preparation of Al 18 F-PSMA-BCH will need to take out a lot of free carrier-free 18 F-, which greatly increases the radioactivity to which operators are directly exposed, and operators often suffer from radiation damage due to unnecessary overexposure

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