Remote control of light-triggered virotherapy

Abstract

Ironized viral particles such as ironized adeno-associated viral particles, which may carry a photosensitizer such as a KillerRed protein, and uses thereof in light-triggered virotherapy against tumor.

Description

[0001] Cross References to Related Applications [0002] This case asserts the benefit of U.S. Provisional Application 62 / 417,946, filed November 4, 2016, the contents of which are hereby incorporated by reference in their entirety. Background technique [0003] In the innovative treatment of cancer, virotherapy is a potential cancer therapeutic agent currently evaluating several viruses from different virus families in clinical trials (Bell et al., Cell Host Microbe, 2014; Russell et al., Nat . Biotechnol., 2012; Miest et al., Nat. Rev. Microbiol., 2014). In most clinical trials of virotherapy, patients receive virotherapy by intratumoral injection (Miest et al., Nat. Rev. Microbiol., 2014). In cancer therapy, enhanced systemic delivery of viruses remains an obstacle to effective virotherapy (Ledford, Nature, 2015; Bell et al., Cell Host Microbe, 2014; Russell et al., Nat. Biotechnol., 2012; Miest et al. al., Nat. Rev. Microbiol., 2014; Kotterman et al., Nat. Rev. Genet., 2...

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