Construction method of animal model for medical research and corresponding equipment

A technology of animal model and construction method, which is applied in medical science, veterinary instruments, veterinary surgery, etc., can solve the problems of nerve root injury, large range of action of medicinal liquid, and influence on modeling effect, etc., and achieve high modeling rate, long-lasting effect

Inactive Publication Date: 2020-05-08
GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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Problems solved by technology

However, due to the relatively large range of action of the drug solution after drug injection, it may cause damage to other nerve roots and affect the modeling effect

Method used

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  • Construction method of animal model for medical research and corresponding equipment

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Embodiment Construction

[0019] The present invention will be described in further detail below by referring to the examples, but these descriptions do not limit the present invention in any form. Unless otherwise defined, all scientific and technical terms used herein have the meaning commonly understood by one of ordinary skill in the art to which this invention belongs.

[0020] Ten 8-month-old male New Zealand rabbits were used, and they were raised in ordinary grade, with a weight of about 2.5kg. The experimental process was carried out in strict accordance with the requirements of the 2006 Ministry of Science and Technology "Guiding Opinions on Treating Experimental Animals". Experimental animals were anesthetized with 30g / L pentobarbital and 1ml / kg ear vein injection.

[0021] After successful anesthesia, the experimental rabbits were fixed, and a pressure measuring water bag was placed in the anus, which was connected to a Medtronic 8-channel lower gastrointestinal motility analyzer to measur...

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Abstract

The invention discloses a construction method of an animal model for medical research and corresponding equipment. The method comprises the following steps: carrying out positioning puncture on an anesthetized animal by using a radio frequency therapeutic apparatus puncture needle; detecting a nerve root at a located position by using a radio frequency needle, and adjusting the radio frequency needle to a proper position; carrying out energy transmission by using a radio frequency thermal coagulation method at a first temperature; and after cooling, carrying out energy transmission by using aradio frequency thermal coagulation method at a second temperature. The method disclosed by the invention is high in model forming rate, good in durability and suitable for clinical research of various neurogenic fecal incontinence.

Description

technical field [0001] The present invention relates to a model for disease research, in particular to a method for constructing an animal model for medical research and corresponding equipment. Background technique [0002] Fecal incontinence refers to the inability to control exhaust and defecation at will, which is a common clinical symptom, seriously affects the quality of life of patients, and causes a greater mental burden. Because it is often concealed, the incidence rate reported by various epidemiological studies varies greatly (1.4%-18%), and it can reach 50% in the nursing home population. At present, there are few relevant researches in China, and the clinical efficacy is still unsatisfactory. [0003] With the emergence of my country's population aging problem, this contradiction will become more acute. Establishing an animal model is the first step in conducting relevant experimental research, and finding an animal model of fecal incontinence with a high succ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 王晓锋谢珅李华山
Owner GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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