A marker gene snord16 gene and its application

A gene and colon cancer technology, applied in the direction of biochemical equipment and methods, microbial measurement/inspection, etc., can solve the problem of mortality reduction and other issues

Active Publication Date: 2022-03-04
ACADEMY OF MILITARY MEDICAL SCI
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] Colon cancer-related mortality has declined significantly over the past few decades due to improvements in cancer prevention, early diagnosis, and treatment, but there is still room to improve overall outcomes for colon cancer patients

Method used

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  • A marker gene snord16 gene and its application
  • A marker gene snord16 gene and its application
  • A marker gene snord16 gene and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1. Study on the correlation between SNORD16 gene and pathological parameters of colon cancer.

[0023] 1. Patients and tissue samples

[0024] This study analyzed 434 colon cancer patients from The Cancer Genome Atlas (TCGA) database. When evaluating the relationship between SNORD16 expression and clinicopathological parameters, patients with incomplete clinical data were excluded from the study, a total of 279 cases. Complete clinical information includes: patient's gender, age, TNM stage, pathological T stage, lymph node metastasis, distant metastasis, lymphatic invasion, venous invasion, and history of colonic polyps. In addition, 20 pairs of matched colon cancer and adjacent normal mucosal tissues were obtained from the Department of Colorectal Surgery, Cancer Hospital Affiliated to China Medical University, for the evaluation of SNORD16 expression. The ethics committee approved the use of the specimens, and informed consent was obtained from each patient....

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Abstract

The application of the SNORD16 gene in the preparation of a colon cancer detection kit and related kits belong to the field of biotechnology. In order to excavate and identify prognostic biomarkers of high-risk patients and to explore new molecular mechanisms of the pathogenesis of colon cancer, the present invention provides the application of SNORD16 gene in the preparation of colon cancer detection kits. The nucleotide sequence of the SNORD16 gene is as shown in SEQ ID No. .1 shown. The kit is used for colon cancer diagnosis and / or prognosis assessment; compared with normal paracancerous tissues, the SNORD16 gene is highly expressed in colon cancer cells or tissues. The invention also provides related detection kits. In vitro functional experiments show that SNORD16 can promote the growth, proliferation, migration and invasion of colon cancer cells by inhibiting apoptosis, indicating that SNORD16 has oncogenic effects in colon cancer and can also be used as a new diagnostic and prognostic biomarker for colon cancer.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a marker gene SNORD16 gene and its application. Background technique [0002] Colon cancer is considered to be one of the most common and deadly malignancies in both men and women. Its widespread existence requires novel diagnostic and prognostic biomarkers. [0003] Colon cancer-related mortality has declined significantly over the past few decades due to improvements in cancer prevention, early diagnosis, and treatment, but there is still room to improve the overall prognosis of colon cancer patients. To this end, there is an urgent need to explore new prognostic biomarkers that can identify high-risk patients as well as novel molecular mechanisms of colon cancer pathogenesis. Emerging evidence suggests that small nucleolar RNAs (snoRNAs) play key roles in tumor development. [0004] Noncoding RNAs, especially microRNAs and long noncoding RNAs, have been recognized a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/158
Inventor 王治东贺俊彦刘鑫戚振华王琪路雯清
Owner ACADEMY OF MILITARY MEDICAL SCI
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