Construction method of depression model for crab-eating macaques at adolescence and juvenility
A construction method, the technology of cynomolgus monkeys, applied in animal husbandry and other fields, can solve the problems of lack of animal models of adolescent depression, achieve the effects of accurately testing anxiety and depression behaviors, reducing sample size, and saving costs
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[0024] The present invention selects 10 adolescent male cynomolgus monkeys (21-52 months old) and divides them into two groups according to age and body weight. Subjects in the Chronic Unpredictable Stimuli group (CUMS, n=5) were exposed to several unpredictable stimuli for 5 cycles. The control group (CON, n=5) was treated according to daily routine throughout the experiment. Behavior, body weight, and sucrose preference of all monkeys were measured at baseline and at the end of each stimulation period. In addition, the apple craving test (AAT), human trespasser test (HIT), and cortisol levels in hair and blood were measured at the end of the study.
[0025] So the concrete steps of the present invention are as follows:
[0026] 10 adolescent male cynomolgus monkeys (21-52 months old) were selected and divided into chronic unpredictable mild stimulation group (denoted as CUMS group, n=5) and control group (denoted as CON group, n=5) according to age and body weight. =5), s...
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