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Pharmaceutical application of gallic acid

A technology of gallic acid and cervical cancer, applied in the field of medicine, can solve problems such as large side effects, abnormal toxicity, and difficult to cure

Active Publication Date: 2020-07-17
SHANGHAI SPARK PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, there are many anti-cancer drugs that have been approved for marketing in the world, but there are problems such as intractability, large side effects, and even abnormal toxicity of mutagenicity to varying degrees. More effective and safer drugs need to be developed

Method used

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  • Pharmaceutical application of gallic acid
  • Pharmaceutical application of gallic acid
  • Pharmaceutical application of gallic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0031] In order to make the technical means, creative features, goals and effects of the present invention easy to understand, the following examples will specifically describe the pharmaceutical application of gallic acid of the present invention.

[0032] Gallic acid, English name: Gallic acid; Chinese chemical name: 3,4,5-trihydroxybenzoic acid; English chemical name: 3,4,5-trihydroxybenzoic acid; Molecular formula: C 7 h 6 o 5 ; Molecular weight: 170.12; CAS number: 149-91-7; Chemical structure:

[0033]

[0034] Gallic acid has the effect of treating tumors.

[0035]

[0036] This example is an in vitro screening drug efficacy study of anti-tumor drugs.

[0037] The required experimental equipment is shown in Table 1.

[0038] Table 1. Experimental equipment

[0039]

[0040] The required reagents are listed in Table 2.

[0041] Table 2. Main Reagents

[0042]

[0043] The experimental cells used are listed in Table 3.

[0044] Table 3. Experimental cel...

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Abstract

The invention provides a pharmaceutical application of gallic acid. The gallic acid has a tumor treatment effect, and has an obvious inhibition effect on eight different human tumor cells, namely human liver cancer cells, human lung cancer cells (large cell lung cancer), primary colorectal cancer cells, human cervical squamous carcinoma cells, human gastric cancer cells, human prostate cancer cells, human lung adenocarcinoma cells (pleural effusion) and human colorectal adenocarcinoma cells.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medicinal application of gallic acid. Background technique [0002] At present, there are many anti-cancer drugs approved for marketing in the world, but there are problems such as intractability, large side effects, and even abnormal toxicity of mutagenicity to varying degrees. More effective and safer drugs need to be developed. [0003] Gallic acid is an active ingredient of polyphenols in many traditional Chinese medicines, and has biological activities such as anti-tumor, anti-oxidation, and anti-virus [1-2] . Genotoxicity of natural botanicals appears less pronounced, study shows [3] . The activity of gallic acid has been widely studied, and its anti-tumor effects include: (1) low toxic and side effects on normal cells; (2) strong killing effect on various tumors; (3) can be taken orally, its The mechanism of action is relatively clear; (4) widely exists ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P35/00
CPCA61K31/192A61P35/00
Inventor 宋昆元陈伟伟
Owner SHANGHAI SPARK PHARM CO LTD
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