Method for analyzing analgesic effect of active ingredients of nux vomica based on network pharmacology

A technique for the effects of Nuxebra chinensis, applied in the field of network pharmacology analysis of traditional Chinese medicine, can solve the problems of lack of system, single research target, long research cycle of Nuxebra chinensis, etc., and achieve the effect of reducing costs

Active Publication Date: 2020-07-28
GUANGZHOU HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

[0004] This invention aims to provide a method based on network pharmacology to analyze the analgesic effect of active ingredients of Nuxebra chinensis, effectively combining complex network analysis technology and big data technol

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  • Method for analyzing analgesic effect of active ingredients of nux vomica based on network pharmacology
  • Method for analyzing analgesic effect of active ingredients of nux vomica based on network pharmacology
  • Method for analyzing analgesic effect of active ingredients of nux vomica based on network pharmacology

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[0025] In order to have a clearer understanding of the technical features, purposes and beneficial effects of the present invention, the technical solutions of the present invention are described in detail below in conjunction with specific embodiments and accompanying drawings. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the present invention. the scope of the invention.

[0026] 1. A method for analyzing the analgesic effect of the active ingredients of Nuxebra chinensis based on network pharmacology

[0027] Include the following steps:

[0028] S1. Obtaining the chemical composition and compositional action target of Nuxebra chinensis:

[0029] With "Nyxony" as the keyword (such as "Nyxony", the English name is MAQIANZI), using web crawler technology, forwarding the user's query request to BATMAN-TCM ( http: / / bionet.ncpsb.org / batman-tcm / index.php / Home / Index / index) database, retrieved from t...

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Abstract

The invention discloses a method for analyzing the analgesic effect of active ingredients of nux vomica based on network pharmacology. The method comprises the following steps: S1, obtaining chemicalcomponents and component action targets of nux vomica, wherein nux vomica is used as a keyword, and retrieving is performed by utilizing a BATMAN-TCM database to obtain a nux vomica active compound meeting conditions and a targeting gene thereof; S2, identifying a disease action target, wherein a virtual target gene related to pain is acquired by using a DisGeNET database, and intersection is performed on the nux vomica active compound and the target gene thereof to obtain a drug-disease intersection target gene; S3, constructing a nux vomica and disease network, and screening a core node; andS4, performing GO enrichment and KEGG pathway annotation analysis on the core node by using the DAVID, predicting target function distribution, analyzing the enrichment degree of the core pathway according to the enrichment factor, and analyzing the nux vomica analgesic action mechanism. With the method, the problems of long nux vomica research period, lack of systematicness, single research target and the like at present are solved.

Description

technical field [0001] The invention relates to the technical field of network pharmacology analysis of traditional Chinese medicine, in particular to a method for analyzing the analgesic effect of active ingredients of Nuxebra chinensis based on network pharmacology. Background technique [0002] Traditional Chinese medicine treats patients as a system with different states. It has a long history and has accumulated a large number of prescriptions. The overall concept of traditional Chinese medicine has something in common with the core ideas of cutting-edge technologies such as network pharmacology and network biology, and also meets the needs of systematic treatment of complex diseases such as tumors. The research in the new field of "Chinese medicine network pharmacology" aims to reveal the mysteries of traditional Chinese medicine prescriptions from the system level and molecular level, and promote the research of Chinese medicine from the current "single target, single...

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Application Information

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IPC IPC(8): G16B15/30G16H50/70G16H70/40
CPCG16B15/30G16H70/40G16H50/70Y02A90/10
Inventor 邓志军郭洁文刘若轩
Owner GUANGZHOU HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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