Method for analyzing analgesic effect of active ingredients of nux vomica based on network pharmacology

Abstract

The invention discloses a method for analyzing the analgesic effect of active ingredients of nux vomica based on network pharmacology. The method comprises the following steps: S1, obtaining chemicalcomponents and component action targets of nux vomica, wherein nux vomica is used as a keyword, and retrieving is performed by utilizing a BATMAN-TCM database to obtain a nux vomica active compound meeting conditions and a targeting gene thereof; S2, identifying a disease action target, wherein a virtual target gene related to pain is acquired by using a DisGeNET database, and intersection is performed on the nux vomica active compound and the target gene thereof to obtain a drug-disease intersection target gene; S3, constructing a nux vomica and disease network, and screening a core node; andS4, performing GO enrichment and KEGG pathway annotation analysis on the core node by using the DAVID, predicting target function distribution, analyzing the enrichment degree of the core pathway according to the enrichment factor, and analyzing the nux vomica analgesic action mechanism. With the method, the problems of long nux vomica research period, lack of systematicness, single research target and the like at present are solved.

Description

technical field [0001] The invention relates to the technical field of network pharmacology analysis of traditional Chinese medicine, in particular to a method for analyzing the analgesic effect of active ingredients of Nuxebra chinensis based on network pharmacology. Background technique [0002] Traditional Chinese medicine treats patients as a system with different states. It has a long history and has accumulated a large number of prescriptions. The overall concept of traditional Chinese medicine has something in common with the core ideas of cutting-edge technologies such as network pharmacology and network biology, and also meets the needs of systematic treatment of complex diseases such as tumors. The research in the new field of "Chinese medicine network pharmacology" aims to reveal the mysteries of traditional Chinese medicine prescriptions from the system level and molecular level, and promote the research of Chinese medicine from the current "single target, single...

AI Technical Summary

Problems solved by technology

[0004] This invention aims to provide a method based on network pharmacology to analyze the analgesic effect of active ingredients of Nuxebra chinensis, effectively combining complex network analysis technology and big data technology To get up, analyze and calculate the potential action targets of the active ingredients of Nuxebra chinensis, and solve the problems of long research cycle, lack of systematicness and single research goal of Nuxebra chinensis.

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