Kit for detecting ultra-early Parkinson's disease

Abstract

The invention discloses a kit for detecting ultra-early Parkinson's disease, and belongs to the technical field of biological detection. The kit comprises an alpha-synuclein detection unit, a serum iron detection unit, a serum zinc detection unit, a GSH detection unit, a GSH-Px detection unit and an SOD detection unit. According to the kit, serum alpha-synuclein, metal ions Fe and Zn and GSH, GSH-Px and SOD are detected, related indexes of PD are comprehensively and jointly detected, the kit can be effectively used for auxiliary diagnosis of the ultra-early Parkinson's disease, and the sensitivity and specificity of auxiliary diagnosis are improved. Meanwhile, a required sample is blood, and compared with cerebrospinal fluid extraction and detection, the kit is more convenient and simplerand is more beneficial to clinical popularization.

Description

technical field [0001] The invention belongs to the technical field of biological detection, and in particular relates to a kit for ultra-early detection of Parkinson's disease. Background technique [0002] Parkinson's disease (PD) is the most common degenerative movement disorder of the central nervous system and the second most common neurodegenerative disease in the world after Alzheimer's disease. The clinical manifestations of Parkinson's disease mainly include motor symptoms such as resting tremor, muscle rigidity, bradykinesia, and abnormal posture and gait, in addition to non-motor symptoms such as depression, sleep disturbance, constipation, and cognitive impairment. According to epidemiological statistics, there are about 2.5 million PD patients in my country, and the prevalence rate of people over 65 years old is 1700 / 100,000, and it increases with age. According to the prediction of the World Health Organization experts, by 2030, Chinese PD patients will accoun...

AI Technical Summary

Problems solved by technology

However, the main disadvantages of detecting PD protein biomarkers in cerebrospinal fluid are: 1) the collection of cerebrospinal fluid is difficult, which causes great damage to patients, and it is generally difficult for patients to accept it clinically; 2) there is a lack of protein markers for early warning and diagnosis. The protein markers in cerebrospinal fluid can only diagnose middle and advanced PD, but cannot detect potential PD patients early; 3) the sensitivity is low. Low-to-medium abundance protein markers are not sensitive enough, and the cost of using high-sensitivity electrochemiluminescence methods (such as MSD technology) is high

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