Early non-small cell lung cancer recurrence model construction method based on DNA methylation

A technology of non-small cell lung cancer and construction method, which is applied in the field of early non-small cell lung cancer recurrence model construction based on DNA methylation, can solve the problems of unreasonable prediction of non-small cell lung cancer recurrence, and reduce the possibility, strong resistance Good acceptance and uniformity

Active Publication Date: 2020-08-21
WEST CHINA HOSPITAL SICHUAN UNIV
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Problems solved by technology

[0007] The technical problem to be solved by the present invention is to provide a method for constructing an early non-small cell lung cancer recurrence model based on DNA methylation, so as to solve the problem that the current non-small cell lung cancer recurrence model is unreasonable in predicting the recurrence of non-small cell lung cancer

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  • Early non-small cell lung cancer recurrence model construction method based on DNA methylation
  • Early non-small cell lung cancer recurrence model construction method based on DNA methylation
  • Early non-small cell lung cancer recurrence model construction method based on DNA methylation

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Embodiment Construction

[0041] In order to solve the problem that the current non-small cell lung cancer recurrence model is unreasonable in predicting the recurrence of non-small cell lung cancer, the present invention provides a method for predicting the recurrence of early non-small cell lung cancer based on DNA methylation, which mainly includes establishing the recurrence of non-small cell lung cancer Models and predictions of recurrence using a non-small cell lung cancer model.

[0042] 1. Establishment of non-small cell lung cancer recurrence model

[0043] 1. Collect early non-small cell lung cancer cases, and extract DNA from tumors and adjacent normal tissues of case patients, and perform methylation sequencing;

[0044] 2. For the sequencing data in step 1, calculate the coverage and beta value of the methylation site;

[0045] 3. For methylation sites, search and merge highly correlated methylation sites to form corresponding methylation intervals;

[0046] 4. According to the type of m...

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Abstract

The invention relates to the field of biomedicine, and discloses an early-stage non-small cell lung cancer recurrence model construction method based on DNA methylation. The invention aims to solve the problem of unreasonable non-small cell lung cancer recurrence prediction of a conventional non-small cell lung cancer recurrence model. According to the method, directed at methylation sites, the methylation sites with high correlation are searched and merged to form a corresponding methylation interval; then according to the types of methylation chips, methylation sites/intervals which can be detected by chip probes are selected as training data to establish a methylation risk score model containing one methylation interval and eight methylation sites, namely a non-small cell lung cancer recurrence model; and the methylation risk score model has a plurality of score thresholds that may match scores calculated by the methylation risk score model with one selected from a high score group,a medium score group and a low score group. The constructed model is suitable for predicting recurrence of non-small cell lung cancer.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a method for constructing an early non-small cell lung cancer recurrence model based on DNA methylation. Background technique [0002] Non-small cell lung cancer is the leading cause of death from cancer worldwide. Low-dose CT can screen out early-stage lung cancer patients in the population. Surgical resection and postoperative adjuvant therapy for these patients can significantly improve their overall survival rate, but still more than 25% of early-stage (T2N0M0) patients will experience postoperative recurrence , and postoperative recurrence is the main cause of poor prognosis. Considering the extensive heterogeneity of lung cancer, it is an important scientific issue to accurately identify the high-recurrence population among early-stage lung cancer patients. The latest National Comprehensive Cancer Network (NCCN) guidelines recommend six high-risk factors, including tumor differ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B5/00G16B20/30G16B40/00G16H50/50C12Q1/6886
CPCG16B5/00G16B20/30G16B40/00G16H50/50C12Q1/6886C12Q2600/154
Inventor 刘伦旭邓雨岚邓森议陈楠苏雨桃
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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