A new triton-silver compound antibacterial reagent and its application

A compound antibacterial and reagent technology, which is applied in the field of Triton-silver composite antibacterial new reagents, to achieve the effects of reducing high cytotoxicity and potential discoloration defects, improving antibacterial effect, and reducing usage

Active Publication Date: 2021-07-20
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When CHX is used in combination with silver ions or nano-silver, it shows that its antibacterial effect is enhanced, but a new type of enhanced anti-bacterial drug agent has been developed by synergizing silver ions or nano-silver and TX-100, which has not been reported yet.

Method used

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  • A new triton-silver compound antibacterial reagent and its application
  • A new triton-silver compound antibacterial reagent and its application
  • A new triton-silver compound antibacterial reagent and its application

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Embodiment Construction

[0027] Triton-silver composite antibacterial new reagent and its application in the present invention will be further described below in conjunction with the accompanying drawings by specific embodiments, but this should not be interpreted as the scope of the present invention is limited to the following examples, all based on the above-mentioned of the present invention The technologies realized by the contents all belong to the scope of the present invention.

[0028] Taking the mixed solution of silver ions and TX-100 as an example, for Enterococcus faecalis, a gram-positive facultative anaerobic bacterium that has strong resistance to extremely harsh environments, such as nutrient deficiency and high alkaline pH value, it is The performance of the above-mentioned new antibacterial drugs was determined.

[0029] The mensuration of embodiment silver ion and TX-100 mixed solution synergistic antibacterial property

[0030] 1.1 Minimum inhibitory concentration (MIC) and bacte...

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Abstract

The invention provides a new triton-silver composite antibacterial reagent and its application. The new triton-silver composite antibacterial reagent is made of triton and silver as raw materials, and a pharmaceutically acceptable carrier is added to prepare a compound with excellent antibacterial properties. A new type of antibacterial drug agent with high performance, the silver is silver ion or nano silver, the concentration of triton is lower than 1%, and the concentration of silver ion or nano silver is lower than 100 μg / mL. The triton and silver have synergistic antibacterial effect. The new triton-silver composite antibacterial agent provided by the present invention can effectively reduce the amount of silver ions or nano-silver used, thereby significantly reducing its accompanying high cytotoxicity and potential discoloration defects, and significantly improving the antibacterial effect of silver ions or nano-silver , has important research and clinical significance.

Description

technical field [0001] The invention belongs to the field of antibacterial drug reagents, and in particular relates to a new triton-silver composite antibacterial reagent and application thereof. Background technique [0002] Antibacterial drugs are one of the most widely used drugs in clinical practice. The combined application of different antibacterial drugs has a long history. Reasonable combination of drugs has incomparable advantages over single drugs, which can not only reduce adverse reactions, reduce drug-induced diseases, but also reduce drug resistance and improve curative effect. [0003] Antibacterial metal ions, such as silver ions (Ag + ) has no obvious bacterial drug resistance while having broad-spectrum antibacterial activity. However, the high cytotoxicity and potential discoloration of silver ions severely restrict its wide application in clinical medicine. Detergents are widely used as biofilm solubilizers and can be divided into ionic surfactants (s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/635A61K33/38A61K31/09A61K31/77A61P31/04
CPCA61K31/09A61K31/77A61K33/38A61P31/04A61K2300/00
Inventor 范伟范兵段梦婷
Owner WUHAN UNIV
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