Traditional Chinese medicine composition capable of inhibiting tumor cell activity and drug resistance, its preparation method and application

A technology of tumor cells and drug resistance, applied in anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., can solve problems such as patient recurrence

Active Publication Date: 2022-06-03
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, despite the high response rate of CAR-T therapy, many patients still relapse after treatment

Method used

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  • Traditional Chinese medicine composition capable of inhibiting tumor cell activity and drug resistance, its preparation method and application
  • Traditional Chinese medicine composition capable of inhibiting tumor cell activity and drug resistance, its preparation method and application
  • Traditional Chinese medicine composition capable of inhibiting tumor cell activity and drug resistance, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] A traditional Chinese medicine composition with tumor cell inhibiting activity and drug resistance, comprising the following raw materials by weight: 20 parts of licorice, 20 parts of Qianghuo, 20 parts of Hedyotis diffusa, 10 parts of Treats, 10 parts of Cnidium, and 10 parts of wild chrysanthemum servings, 5 servings turmeric and 5 servings ginger.

[0072] The above-mentioned traditional Chinese medicine composition is recorded as AECHC1, and its preparation method includes the following steps: mixing the components, pulverizing, passing 120 meshes to obtain powder, then adding 75% ethanol to the powder to soak for 1 month, and finally taking the supernatant to pass 0.45 μm filter membrane, prepared; wherein, the weight ratio of powder and 75% is 1:4.

Embodiment 2

[0074] A traditional Chinese medicine composition with tumor cell inhibiting activity and drug resistance comprises the following raw materials in parts by weight: 30 parts of licorice, 20 parts of Qianghuo, 20 parts of Hedyotis diffusa, 15 parts of Treats and 15 parts of Arborvitae.

[0075] The above-mentioned traditional Chinese medicine composition is recorded as AECHC2, and its preparation method includes the following steps: mixing the components, pulverizing, passing 120 meshes to obtain powder, then adding 75% ethanol to the powder and soaking for 1 month, and finally taking the supernatant to pass 0.45 μm filter membrane, prepared; wherein, the weight ratio of powder and 75% is 1:4.

Embodiment 3

[0077] A traditional Chinese medicine composition with tumor cell inhibiting activity and drug resistance comprises the following raw materials in parts by weight: 30 parts of licorice, 25 parts of Qianghuo, 25 parts of Hedyotis diffusa and 20 parts of Treats.

[0078] The above-mentioned traditional Chinese medicine composition is recorded as AECHC3, and its preparation method includes the following steps: mixing the components, pulverizing, passing 120 meshes to obtain a powder, then adding 75% ethanol to the powder to soak for 1 month, and finally taking the supernatant to pass 0.45 μm filter membrane, prepared; wherein, the weight ratio of powder and 75% is 1:4.

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Abstract

The invention provides a traditional Chinese medicine composition capable of inhibiting tumor cell activity and drug resistance, and its preparation method and application. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20-40 parts of licorice, 15-25 parts of notopterygium, white flower Hedyotis 15-25 parts, Cnidium 0-10 parts, Phellodendron 5-20 parts, Arborvitae leaves 0-15 parts, wild chrysanthemum 0-10 parts, rosin 0-10 parts, turmeric 0-5 parts and ginger 0 parts -5 servings. The present invention obtains a traditional Chinese medicine composition with the activity of inhibiting tumor cells and drug resistance through reasonable formulation and screening. The components in the composition are mixed, and after alcohol extraction, the proliferation, migration and Invasion, while effectively reducing the expression of drug resistance genes and enhancing the sensitivity of cancer cells to drugs.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and in particular relates to a traditional Chinese medicine composition with tumor cell inhibiting activity and drug resistance, and a preparation method and application thereof. Background technique [0002] Cancer is a general term for malignant tumors. Cancer, as a malignant disease that seriously threatens human life and health, has become one of the common and frequently-occurring diseases with the highest incidence. healthy life. Recent statistics in my country show that the number of deaths caused by tumors has exceeded that of cardiovascular diseases. In January 2019, the National Cancer Center released the latest edition of its National Cancer Statistics. It is estimated that there were about 3.929 million new cases of malignant tumors in China in 2015, of which about 2.151 million were male and 1.778 million were female. On average, 7.5 people were diagnosed with cancer eve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P35/00
CPCA61K36/484A61K36/237A61K36/748A61K36/756A61K36/234A61K36/287A61K36/9066A61K36/9068A61P35/00A61K2236/333A61K2300/00Y02A50/30
Inventor 茆灿泉敖智广王思怡王隽李迪强李栋杨蕾
Owner SOUTHWEST JIAOTONG UNIV
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