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Bio-reachable prediction tool with biological sequence selection

A biological sequence and sequence technology, applied in the field of genetic engineering to improve cells, can solve problems such as time-consuming and error-prone optimal enzymes

Pending Publication Date: 2021-03-30
ZYMERGEN INC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the BPT of such embodiments can predict a large number of pathways, each containing multiple reactions (e.g., 10 pathways, each containing 10 reactions, or even more), for which optimal enzymes are manually determined is time consuming and error prone

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  • Bio-reachable prediction tool with biological sequence selection
  • Bio-reachable prediction tool with biological sequence selection
  • Bio-reachable prediction tool with biological sequence selection

Examples

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Embodiment Construction

[0040] The description proceeds with reference to the accompanying drawings, in which various example embodiments are shown. However, many different example embodiments may be utilized, and thus this description should not be construed as limited to the example embodiments set forth herein. Rather, these example embodiments are provided so that this disclosure will be thorough and complete. Various modifications to the exemplary embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments and applications without departing from the spirit and scope of the present disclosure. Thus, the present disclosure is not intended to be limited to the embodiments shown but is to be accorded the widest scope consistent with the principles and features disclosed herein.

[0041] The inventors have recognized that conventional methods for predicting viable target molecules suffer from the following obstacles:...

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Abstract

Systems, methods and non-transitory computer-readable media identify a candidate biological sequence for enabling a function in a host cell. Embodiments access a predictive model that associates a plurality of biological sequences, such as enzymes, with one or more functions, such as reaction catalysis; predict, using the predictive model, that one or more candidate sequences of the plurality of biological sequences enable a desired function; and classify using a processor, candidate sequences that satisfy a confidence threshold as filtered candidate sequences.

Description

[0001] Cross References to Related Applications [0002] This application claims U.S. Provisional Application No. 62 / 764,819, filed August 15, 2018, U.S. Provisional Application No. 62 / 720,811, filed August 21, 2018, U.S. Provisional Application No. 62, filed August 15, 2018 / 764,861 and U.S. Provisional Application No. 62 / 720,839, filed August 21, 2018, all of which are incorporated herein in their entirety. [0003] This application is related to PCT Application No. PCT / US2018 / 018234, filed February 14, 2018 (“BPT PCT Application”) and U.S. Provisional Application No. 62 / 459,558, filed February 15, 2017, which are incorporated by reference as It is incorporated herein in its entirety. [0004] Statement of Government Interest [0005] This invention was made with United States Government support under Agreement No. HR0011-15-9-0014 awarded by DARPA. The government has certain rights in this invention. [0006] sequence listing [0007] This application contains a Seq...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B20/00G16B40/20G16B40/30G16B50/10
CPCG16B20/00G16B40/20G16B40/30G16B50/10Y02A90/10G16B30/10G16B5/00G06N20/00G06N3/08G16B5/20
Inventor A·乔杜里E·J·迪安A·G·希勒S·季莫申科M·L·温
Owner ZYMERGEN INC
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