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A nutritional composition for promoting growth catch-up of low-weight infants and young children

A nutritional composition, technology for infants and young children, applied in the directions of bacteria, application, food science, etc. used in food preparation

Active Publication Date: 2021-11-12
BIOSTIME GUANGZHOU HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few published research results on the regulatory effect of OPN on obesity, especially the effect on the weight of infants and young children has not been reported.

Method used

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  • A nutritional composition for promoting growth catch-up of low-weight infants and young children
  • A nutritional composition for promoting growth catch-up of low-weight infants and young children
  • A nutritional composition for promoting growth catch-up of low-weight infants and young children

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 The relationship between specific types of breast milk oligosaccharides and infant body weight 1 28 infant volunteers were recruited from the hospital, and the selection criteria were healthy, full-term infants (gestational age ≥ 37 weeks), vaginal delivery; medically certified healthy infants: asymptomatic and without disease signs. The mothers of the infants participating in the experiment will sign an informed agreement and guarantee exclusive breastfeeding during the experiment.

[0020] 2By collecting mother's breast milk samples and measuring the baby's weight in the first month T1 (30d±2d), the second month T2 (60d±2d), and the third month T3 (90d±2d). 28 infants were divided into high-weight group and low-weight group for analysis, and the contents of 22 kinds of breast milk oligosaccharides in mother's breast milk were measured in three periods. Through statistics, it was found that the content of specific types of breast milk oligosaccharides was...

Embodiment 2

[0031] Example 2 The growth catch-up effect of breast milk oligosaccharides on low birth weight infants

[0032] Through the study, it was found that the types of breast milk oligosaccharides with high content in the high body weight group were LDFT and 3'-SL, and the types of breast milk oligosaccharides were related to the weight of infants. It is envisaged that growth catch-up in low birth weight infants could be achieved by supplementation with OPN and specific human milk oligosaccharides. Therefore, the following formula was designed to verify the efficacy of breast milk oligosaccharides through animal experiments.

[0033] Growth catch-up validation recipes are grouped as follows:

[0034] Group 1: 70mg LDFT+120mg 2’-FL+100mg LNnT

[0035] Group 2: 70mg 3’-SL+120mg 2’-FL+100mg LNnT

[0036] Group 3: 70mg LDFT+70mg 3’-SL+120mg 2’-FL+100mg LNnT

[0037] Group 4: 6mg OPN+70mg LDFT+70mg 3’-SL+120mg 2’-FL+100mg LNnT Control group: 120mg2’-FL+100mg LNnT

[0038]During u...

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Abstract

The present invention relates to a nutritional composition comprising osteopontin (OPN) and lactooligosaccharides, said nutritional composition comprising at least a high concentration of osteopontin, one sialylated oligosaccharide and at least one N-acetylated The oligosaccharides, the nutritional composition can be used for growth catch-up and healthy growth of infants.

Description

technical field [0001] The present invention relates to a nutritional composition comprising osteopontin and specific human milk oligosaccharides, said nutritional composition comprising at least a high concentration of osteopontin, one sialylated oligosaccharide and at least one N-acetylated oligosaccharide Sugar, for the growth catch-up and healthy growth of infants and young children. Background technique [0002] Catch-up growth refers to the phenomenon of accelerated growth of infants whose growth is retarded due to pathological factors after eliminating the pathological factors, and the best period is the first year after birth. Low birth weight infants are prone to catch-up growth. Low birth weight infants refer to neonates weighing <2500 g at delivery. At present, it has been found that low birth weight of newborns is mainly affected by non-genetic factors, including fetal intrauterine development and pregnancy time. Malnutrition before pregnancy, if you do not...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L33/125A23L33/17A23L33/21A23L33/135
CPCA23L33/125A23L33/17A23L33/21A23L33/135A23V2002/00A23V2400/137A23V2400/143A23V2400/147A23V2400/151A23V2400/157A23V2400/165A23V2400/181A23V2400/125A23V2400/215A23V2400/219A23V2400/123A23V2400/245A23V2400/113A23V2400/175A23V2400/513A23V2400/515A23V2400/519A23V2400/529A23V2400/531A23V2400/533A23V2400/249A23V2400/169A23V2250/28A23V2250/612A23V2250/5424A23V2200/332A23V2250/606A23V2250/5062A23V2250/638
Inventor 陈桔淳刘斐童王园园郑雨星乔纳森.莱恩王宇葶曹玮倩黎勇
Owner BIOSTIME GUANGZHOU HEALTH PROD
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