31 results about "Bone bridge" patented technology

An orthopedic bone bridge, suitable for internally fixating and stabilizing fractured bones. The bone bridge includes: first and second bone plates for attachment to bone fragments by bone screws or the like on opposite sides of a bone fracture, a pair elongate parallel hollow legs on which the plates are mounted and the second plate is slidably engaged and is moveable with respect to the first plate, and an elastic cable or microcable attached to the first plate and extending down through the legs and around said second plate. The elastic cable is configured to provide a controlled tensile force between the plates when they are pulled into a longitudinally spaced apart position with the bone bridge then applying a correspondingly compressive force onto the bone fracture when the plates are secured to bone fragments on opposite sides of a bone fracture.

The invention relates to a meniscus transplanting bone bridge inlaying technology and device and belongs to the field of medical devices. The meniscus transplanting bone bridge inlaying device is composed of a meniscus fixing table (1), a sighting device (2), a guide pin (3), a guide pin sleeve pipe (4), a drill bit sleeve pipe (5), a hollow drill (6), a semicircular bone chisel (7), a socket wrench (8), a drill bit (9) and an allen wrench (10). The meniscus transplanting bone bridge inlaying device is characterized in that a cutting edge is arranged at the left end of the hollow drill (6), a quick change interface is arranged at the right end of the hollow drill (6) and can be connected with a universal quick change handle, the center of the semicircular bone chisel (7) is provided with a through hole, a knife body is semicircular, the head of the semicircular bone chisel (7) is provided with a cutting edge, and the head of the socket wrench (8) is provided with the allen wrench. Under monitoring of an arthroscope, a bone bridge is manufactured, and a bone bridge inlaying operation is performed through small incision of the skin.

The invention discloses a method for preparing a hydroxyapatite coat / surface activated titanium-based composite coat. The method comprises the following steps: 1) performing surface biological activation treatment on titanium or titanium alloy serving as a base material to form a titanium gel layer, and cleaning and drying the titanium base material; 2) preserving the heat of the titanium base material at a high temperature to form an oxidized titanium film; 3) synthesizing hydroxyapatite by using a wet method, and sintering, crushing and sieving the hydroxyapatite to obtain powder; 4) preparing a thin hydroxyapatite coat on the oxidized titanium film by using plasma spraying technology; and 5) putting the hydroxyapatite coat product in a container, and drying the treated product by usingwater vapor to obtain the hydroxyapatite coat / surface activated titanium-based composite coat. The process is simple; when an obtained coat compound implanted material is implanted to the human body,the material plays a role in bone bridge connection of the hydroxyapatite at the early stage, provides rich calcium and phosphorus elements for bone growth, accelerates the growth of a new bone, and shortens an operation healing stage; and when the hydroxyapatite coat is basically degraded, the bone texture and the metal surface form a direct chemical bond combination.

The invention provides a surface physically modified polyarylether bone implant material containing a phthalazinone biphenyl structure and a preparation method thereof. A polyaryl ether nitrile with an osteogenic active coating on the surface, and a functional coating is prepared on the polyaryl ether surface of the polyaryl ether, and the functional coating includes a bioactive bone morphogenetic substance adsorbed by physisorption protein layer. The biologically active protein layer includes bone morphogenetic protein, collagen, osteopontin, plasma fibrin, etc., and the protein layer is loaded onto the surface of the polyarylene xaphthalene by physical adsorption. The surface physical adsorption of proteins involves the adsorption of proteins to functional groups on the surface of polyarylene ether or monolayers with active functional groups. The three-dimensional surface structure and functionalized coating of the invention can improve the osteogenic activity of the polyarylether.

The invention discloses the application of osteopontin as a target molecule in regulating intestinal flora colonization; specifically: inhibiting the expression of OPN gene or blocking the combination of OPN and cell receptors, thereby increasing the number of probiotics in the intestinal tract; blocking OPN Binding to cellular receptors or inhibiting Notch signaling can enhance bacterial adhesion to intestinal epithelial cells. The present invention confirms that osteopontin affects the adhesion between cells and bacteria by inhibiting the expression of cell adhesion factors, thereby inhibiting the colonization of bacteria in the intestinal tract.

The present invention relates to a nutritional composition comprising osteopontin (OPN) and lactooligosaccharides, said nutritional composition comprising at least a high concentration of osteopontin, one sialylated oligosaccharide and at least one N-acetylated The oligosaccharides, the nutritional composition can be used for growth catch-up and healthy growth of infants.

The present invention relates to the technical field of medical devices, and provides a 3D printed lateral meniscus graft substitute with a bone bridge-like fixation structure and a manufacturing method thereof, comprising the following steps: step 1, performing nuclear magnetic resonance imaging on the patient's knee joint, Obtain the two-dimensional nuclear magnetic image of the knee joint; step two, import the two-dimensional nuclear magnetic image of the knee joint into the medical reverse software Mimics, and construct a three-dimensional model of the lateral meniscus; step three, import the three-dimensional meniscus model into Geomagic The software performs the optimization process of the triangular surface to improve the smoothness of the model surface; step 4, import the three-dimensional meniscus model after the optimization process into SOLIDWORKS engineering software, and add a "bone bridge" structure between the front and rear corners; step 5, insert the The three-dimensional model of the meniscus with the "bone bridge" structure added is imported into the printer for 3D printing of the lateral meniscus graft substitute product.

The invention discloses a preparation method of an injectable hydrogel for children's epiphyseal plate regeneration. The main steps are: 1. The outer layer is an anti-bone bridge formation factor and the inner layer is a cartilage differentiation-promoting factor by using a flow focusing method and a microfluidic control method. 2. Mix SA microspheres with bone marrow mesenchymal stem cells in hydrogel to prepare bioink. The hydrogel is injected into the epiphyseal plate cartilage injury, through the local, timed and quantitative release of Enbrel ® +Bevacizumab and IGF‑1 can inhibit the formation of bone bridge and then promote the regeneration and repair of epiphyseal cartilage, providing new ideas and methods for solving the problem of "repair of epiphyseal injury".

A cushion includes a cushion core, adopting blasted sponge, and the cushion core comprising a main bearing area and an auxiliary bearing area; an outer cover layer, wrapping an outer layer of the cushion core, and the outer cover layer adopting a fiber material which is of a reticular structure; and a reinforcing skeleton comprising a plurality of bone bridges, and each bone bridge comprising an arch base and an arch bridge. For each bone bridge, the arch base is located at two side-by-side corners of one side of the cushion core, and is close to one side of the main bearing area; one end of the arch bridge is connected to the arch base, and the other end of the arch bridge extends to a diagonal opposite corner of the other side of the cushion core, and is close to one side of the auxiliary bearing area.

The present invention provides a nutritional composition for improving the intestinal microecology and learning and memory ability of infants fed by elderly mothers and its use in the preparation of infant formula milk powder or probiotic products. The nutritional composition contains 20% by weight ‑35% sialylated oligosaccharides, 50%‑60% fucosylated neutral oligosaccharides, 5%‑30% non-fucosylated neutral oligosaccharides, and / or 0.5%-5% osteopontin (OPN), the sialylated oligosaccharides comprising one of sialylated-lactose-N-tetraose c (LSTc) or sialylated-lactose-N-tetraose b (LSTb) one or two kinds, the neutral oligosaccharides of fucosylation comprising 2-fucosyllactose (2-FL), lacto-N-fucopentaose I II (LNFP I II) or lacto- One or more of N-difucohexaose II (LNDFHII); the non-fucosylated neutral oligosaccharides include lacto-N-neotetraose (LNnT).

The invention discloses a characteristic peptide of osteopontin and application thereof. The amino acid sequence of the characteristic peptide is GDSVAYGLK. The present invention obtains the internal standard peptide corresponding to the characteristic peptide by screening the characteristic peptide of osteopontin, and realizes the quantitative detection of osteopontin by using the analysis technology of high-performance liquid chromatography and mass spectrometry. The method has better Linearity, sensitivity, recovery and precision.

The invention provides the application of osteopontin in hypoxic-ischemic brain injury, and belongs to the technical fields of biomedicine and molecular biology. The present invention uses proteomics to find that the change of osteopontin is the most obvious in the damaged cortex of HI neonatal mice, and further tests prove that osteopontin may be the link between peripheral macrophage invasion and neuroinflammation in the hypoxic-ischemic brain injury. It is a potential target of the vicious cycle, which proves that osteopontin can be used as a diagnostic and prognostic marker and a potential therapeutic target in hypoxic-ischemic brain injury, so it has good practical application value.