Allogeneic decalcified bone and titanium stent combined material for rhinoplasty filling and preparation method of allogeneic decalcified bone and titanium stent combined material

Abstract

The invention relates to an allogeneic decalcified bone and titanium stent combined material for rhinoplasty filling and a preparation method of the allogeneic decalcified bone and titanium stent combined material. The structure comprises a nasal bone matrix made of a titanium alloy, wherein the nasal bone matrix comprises a nose tip, a nose columella and a nose bridge, and the nose bridge is connected with the nose columella through the nose tip; the surface of the nasal bone matrix is densely covered with multiple holes; hollow bodies are formed in the nasal bone matrix and filled with allogeneic decalcified bones, so that the weight of the structure is reduced. The material has the beneficial effects as follows: by means of the designed bone bridge section, and a prosthesis is tightly contacted with the nasal bones and is prevented from displacement or abrasion; by the aid of the holes in the nose bridge, the body fluid can flow into the holes, human tissue is promoted to grow into the holes, the nose and the nose prosthesis are integrated stably, the nose prosthesis is prevented from moving, falling off and festering, and pain of a patient after surgery is prevented. The method is applicable to allogeneic decalcified bone treatment.

Description

technical field

[0001] The invention relates to the technical field of plastic surgery, in particular to a material for filling allogeneic decalcified bone combined with a titanium bracket for rhinoplasty and a preparation method thereof. Background technique

[0002] Rhinoplasty (facelift) surgery is to change the height and shape of the nose by implanting appropriate materials so that it is in harmony with other parts of the face. It is the most common surgery in the field of plastic surgery.

[0003] In medicine, there are many kinds of rhinoplasty materials, such as medical silicone rubber, autologous cartilage, allogeneic cartilage, animal tendon or ligament, expanded body (polytetrafluoroethylene), hyaluronic acid, etc. There are also many preparation methods for nasal bridge prosthesis. Among them, autologous cartilage is self-sourced, so there will be no rejection and no allergies, but it is difficult to shape during the production process. Animal tendons and ligame...

Examples

preparation example Construction

[0043] refer to image 3 As shown, the present invention also proposes a method for preparing a material for rhinoplasty filling allogeneic decalcified bone combined with titanium scaffold, comprising the following steps:

[0044] A) matrix production, the nasal bone matrix is ​​made of titanium alloy material;

[0045] B) taking bone and obtaining allogeneic cartilage in a sterile environment;

[0046] C) treatment, degreasing, decalcifying, deproteinizing and sterilizing the obtained allogeneic cartilage in sequence;

[0047] D) culturing, assembling the treated allograft cartilage in step C onto the nasal bone matrix, and culturing for 24 hours,

[0048] E) Carve, carve the nasal bone matrix into the required shape after the cultivation in step D).

[0049] Concrete processing in the step C of the present invention comprises:

[0050] (1) immersing the allograft cartilage in a mixed liquid of chloroform and methanol for 6-24 hours; wherein: the volume ratio of chlorofor...

Embodiment 1

[0056] 1. The nasal bone matrix is ​​made of titanium alloy material, and there are many hollow holes on the nasal bone matrix;

[0057] 2. The allogeneic rib cartilage is obtained under a sterile environment; the eleventh or twelfth rib is preferably obtained, cleaned with distilled water and soaked;

[0058] 3. Immerse the allogeneic cartilage in a mixed liquid of chloroform and methanol for 24 hours to degrease; wherein: the volume ratio of chloroform and methanol in the mixed liquid of chloroform and methanol is 1:1, and wash it with distilled water after taking it out;

[0059] 4. Immerse the degreased allograft cartilage in a hydrochloric acid solution with a concentration of 0.5mol / L, and keep stirring for 12 hours for decalcification, and wash it with distilled water after taking it out;

[0060] 5. Immerse the decalcified allogeneic cartilage in a mixed solution of TritonX-100 and ammonia water for 72 hours to deproteinize; wherein, the volume percentage of TritonX-10...

Embodiment 2

[0065] 1. The nasal bone matrix is ​​made of titanium alloy material, and there are many hollow holes on the nasal bone matrix;

[0066] 2. Obtain allogeneic ear cartilage in a sterile environment; clean and soak in distilled water;

[0067] 3. Immerse the allogeneic cartilage in a mixed liquid of chloroform and methanol for 24 hours to degrease; wherein: the volume ratio of chloroform and methanol in the mixed liquid of chloroform and methanol is 1:1, and wash it with distilled water after taking it out;

[0068] 4. Immerse the degreased allograft cartilage in a hydrochloric acid solution with a concentration of 0.6mol / L, and keep stirring for 12 hours for decalcification, and wash it with distilled water after taking it out;

[0069] 5. Immerse the decalcified allogeneic cartilage in a mixed solution of TritonX-100 and ammonia water for 72 hours to deproteinize; wherein, the volume percentage of TritonX-100 in the mixed solution of TritonX-100 and ammonia water is 1 %, the ...

technical field

[0001] The invention relates to the technical field of plastic surgery, in particular to a material for filling allogeneic decalcified bone combined with a titanium bracket for rhinoplasty and a preparation method thereof. Background technique

[0002] Rhinoplasty (facelift) surgery is to change the height and shape of the nose by implanting appropriate materials so that it is in harmony with other parts of the face. It is the most common surgery in the field of plastic surgery.

[0003] In medicine, there are many kinds of rhinoplasty materials, such as medical silicone rubber, autologous cartilage, allogeneic cartilage, animal tendon or ligament, expanded body (polytetrafluoroethylene), hyaluronic acid, etc. There are also many preparation methods for nasal bridge prosthesis. Among them, autologous cartilage is self-sourced, so there will be no rejection and no allergies, but it is difficult to shape during the production process. Animal tendons and ligame...

Examples

preparation example Construction

[0043] refer to image 3 As shown, the present invention also proposes a method for preparing a material for rhinoplasty filling allogeneic decalcified bone combined with titanium scaffold, comprising the following steps:

[0044] A) matrix production, the nasal bone matrix is ​​made of titanium alloy material;

[0045] B) taking bone and obtaining allogeneic cartilage in a sterile environment;

[0046] C) treatment, degreasing, decalcifying, deproteinizing and sterilizing the obtained allogeneic cartilage in sequence;

[0047] D) culturing, assembling the treated allograft cartilage in step C onto the nasal bone matrix, and culturing for 24 hours,

[0048] E) Carve, carve the nasal bone matrix into the required shape after the cultivation in step D).

[0049] Concrete processing in the step C of the present invention comprises:

[0050] (1) immersing the allograft cartilage in a mixed liquid of chloroform and methanol for 6-24 hours; wherein: the volume ratio of chlorofor...

Embodiment 1

[0056] 1. The nasal bone matrix is ​​made of titanium alloy material, and there are many hollow holes on the nasal bone matrix;

[0057] 2. The allogeneic rib cartilage is obtained under a sterile environment; the eleventh or twelfth rib is preferably obtained, cleaned with distilled water and soaked;

[0058] 3. Immerse the allogeneic cartilage in a mixed liquid of chloroform and methanol for 24 hours to degrease; wherein: the volume ratio of chloroform and methanol in the mixed liquid of chloroform and methanol is 1:1, and wash it with distilled water after taking it out;

[0059] 4. Immerse the degreased allograft cartilage in a hydrochloric acid solution with a concentration of 0.5mol / L, and keep stirring for 12 hours for decalcification, and wash it with distilled water after taking it out;

[0060] 5. Immerse the decalcified allogeneic cartilage in a mixed solution of TritonX-100 and ammonia water for 72 hours to deproteinize; wherein, the volume percentage of TritonX-10...

Embodiment 2

[0065] 1. The nasal bone matrix is ​​made of titanium alloy material, and there are many hollow holes on the nasal bone matrix;

[0066] 2. Obtain allogeneic ear cartilage in a sterile environment; clean and soak in distilled water;

[0067] 3. Immerse the allogeneic cartilage in a mixed liquid of chloroform and methanol for 24 hours to degrease; wherein: the volume ratio of chloroform and methanol in the mixed liquid of chloroform and methanol is 1:1, and wash it with distilled water after taking it out;

[0068] 4. Immerse the degreased allograft cartilage in a hydrochloric acid solution with a concentration of 0.6mol / L, and keep stirring for 12 hours for decalcification, and wash it with distilled water after taking it out;

[0069] 5. Immerse the decalcified allogeneic cartilage in a mixed solution of TritonX-100 and ammonia water for 72 hours to deproteinize; wherein, the volume percentage of TritonX-100 in the mixed solution of TritonX-100 and ammonia water is 1 %, the ...

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