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Surface physically modified polyarylether bone implant material containing phthalazinone biphenyl structure and preparation method thereof

A xinone biphenyl, surface physics technology, applied in the direction of prosthesis, coating, tissue regeneration, etc., can solve the low limit of biocompatibility and osteogenic activity, affect the life of PEEK implants, poor osteogenic activity Ideal and other issues, to achieve the effect of improving biocompatibility and osteogenic activity, low cost, and maintaining biological activity

Active Publication Date: 2022-03-29
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, problems such as low biocompatibility and unsatisfactory osteogenic activity have always affected the life of PEEK implants. In order to improve these problems of the material, researchers modified the surface of PEEK and prepared bone-like phosphorus on the surface. Limestone coating with osteogenic protein layer for enhanced biocompatibility and osteogenic activity
However, the low biocompatibility and osteogenic activity of polyarylene ether limit its application as a bone implant material. The present invention intends to prepare a coating with osteogenic activity on the surface of polyarylene ether , to enhance its biocompatibility and osteogenic activity

Method used

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  • Surface physically modified polyarylether bone implant material containing phthalazinone biphenyl structure and preparation method thereof
  • Surface physically modified polyarylether bone implant material containing phthalazinone biphenyl structure and preparation method thereof
  • Surface physically modified polyarylether bone implant material containing phthalazinone biphenyl structure and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] In the first step, the PPBES powder is hot-pressed to obtain a PPBES part;

[0047] In the second step, the PPBES parts are polished with 400-mesh and 2000-mesh sandpaper to make the surface uniform, and PPBES parts with different surface roughness are obtained, PPBES-400 and PPBES-2000; then the polished PPBES parts, Wash with deionized water, ethanol, acetone, and deionized water respectively, and dry for later use;

[0048] In the third step, the PPBES-400 and PPBES-2000 parts were respectively immersed in a PBS solution of BMP-2 with a pH of 7.4, and magnetically stirred at room temperature for 24 hours.

[0049] Finally, the parts were removed from the solution, dried in a 37°C blast oven, and placed in a 4°C refrigerator for later use.

Embodiment 2

[0051] The PPBES among the embodiment one is changed into PPENK, and it is the same as the embodiment one with the step

[0052] The surface morphology of polyarylether materials with different roughness was observed by cold field scanning electron microscope. The hydrophilicity and hydrophobicity of the sample surface were characterized by a water contact angle meter. The surface BMP-2 content was determined by testing the loading efficiency and in vitro release efficiency of BMP-2 by using the BMP-2 content kit. MC3T3-E1 mouse embryonic osteoblast precursor cells were used as test cells to characterize the biocompatibility of the material.

[0053] The surface prepared by the above method has PPBES and PPENK parts with osteogenic active protein, and its properties are as follows:

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Abstract

The invention provides a surface physically modified polyarylether bone implant material containing a phthalazinone biphenyl structure and a preparation method thereof. A polyaryl ether nitrile with an osteogenic active coating on the surface, and a functional coating is prepared on the polyaryl ether surface of the polyaryl ether, and the functional coating includes a bioactive bone morphogenetic substance adsorbed by physisorption protein layer. The biologically active protein layer includes bone morphogenetic protein, collagen, osteopontin, plasma fibrin, etc., and the protein layer is loaded onto the surface of the polyarylene xaphthalene by physical adsorption. The surface physical adsorption of proteins involves the adsorption of proteins to functional groups on the surface of polyarylene ether or monolayers with active functional groups. The three-dimensional surface structure and functionalized coating of the invention can improve the osteogenic activity of the polyarylether.

Description

technical field [0001] The invention relates to a medical polymer implant material, in particular to a surface physically modified polyarylether bone implant material containing a phthalazinone biphenyl structure and a preparation method thereof. Background technique [0002] Bone repair materials are one of the biomedical materials with the greatest clinical demand. As a kind of bone repair materials, bone implant materials have always been paid attention to by people. Because of its unique properties and advantages, polymer bone implant materials account for a large proportion of bone implant materials. The internal environment is a liquid environment, and polymer bone implant materials must meet the requirements of non-toxicity, excellent biocompatibility, chemical stability, suitable physical and mechanical properties, easy processing and molding, and good cost / performance ratio. Among them, excellent biocompatibility and osteogenic activity are the most difficult to sa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/34A61L27/54
CPCA61L27/18A61L27/34A61L27/54A61L2300/252A61L2300/412A61L2430/02C08L71/00
Inventor 蹇锡高柳承德王锦艳刘程张守海胡方圆
Owner DALIAN UNIV OF TECH
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