Method for preparing hydroxyapatite coat/surface activated titanium-based composite coat

A hydroxyapatite and surface activation technology, applied in coatings, medical science, prostheses, etc., can solve problems such as implant failure and implant loosening, shorten the healing period, simplify the process, and accelerate the growth of new bone. Effect

Inactive Publication Date: 2010-08-04
HAINAN UNIVERSITY
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Problems solved by technology

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Method used

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Examples

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Effect test

preparation example Construction

[0014] A preparation method of a hydroxyapatite coating / surface-activated titanium-based composite coating, the steps of which are as follows:

[0015] 1. Use titanium or titanium alloy as the base material for cleaning and drying, and then perform biological activation treatment on the surface of the titanium base material to form a layer of amorphous titanium gel layer; finally wash with deionized water and dry . The treatment method is alkali treatment, acid-alkali combined treatment or hydrogen peroxide-hydrochloric acid combined treatment.

[0016] 2. Put the treated titanium base material in a furnace at 550-650° C. for 15-60 minutes to keep it warm for 15-60 minutes to form a porous anatase structure titanium oxide film with excellent biological activity.

[0017] 3. Synthesize hydroxyapatite by a wet method, sinter it at high temperature, pulverize it, and sieve it to prepare hydroxyapatite powder.

[0018] 4. Prepare a layer of hydroxyapatite coating on the titanium...

Embodiment 1

[0022] Taking titanium as the base material, (1) cleaning the titanium in acetone, absolute ethanol and deionized water respectively with ultrasonic waves, and cleaning each solution three times for five minutes each time. After cleaning, put it into the oven and dry it at 125°C for one hour. (2) Dip titanium into a mixed solution of 98% sulfuric acid, 36% hydrochloric acid and deionized water at a ratio of 1:1:2, and place it at 70° C. for half an hour. Then immerse in a sodium hydroxide solution with a concentration of 0.1 mole, and soak for 5 hours at 70°C. The product is repeatedly rinsed with deionized water and dried before and after each step of soaking. Then put the metal titanium in a furnace at 600°C for half an hour to keep it warm to form a porous anatase structure titanium oxide film with excellent biological activity. (3) Synthesis of hydroxyapatite by wet method. And it is sintered at high temperature, pulverized and sieved to prepare hydroxyapatite powder. ...

Embodiment 2

[0024] Using titanium as the base material, the steps (1) are the same as in Example 1; (2) immerse the sample in 8.8M hydrogen peroxide at 70° C. for 1.5 hours. Rinse 6 times with deionized water and dry. Soak in 0.1M hydrochloric acid at 70°C for 2 hours. After taking it out, rinse it repeatedly 6 times with deionized water and dry it. Subsequently, the metal titanium is placed in a furnace at 550°C for about half an hour, and a porous anatase structure titanium oxide film with excellent biological activity is formed. Step (3) is the same as Embodiment 1 (3); (4) Argon is used as the working gas, supplemented by hydrogen. The working voltage is 40-70 volts, the working current is 300-400 amperes, and the distance from the muzzle to the base material is 60-80cm. Steps (5) (6) are the same as Embodiment 1 (5) (6).

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Abstract

The invention discloses a method for preparing a hydroxyapatite coat/surface activated titanium-based composite coat. The method comprises the following steps: 1) performing surface biological activation treatment on titanium or titanium alloy serving as a base material to form a titanium gel layer, and cleaning and drying the titanium base material; 2) preserving the heat of the titanium base material at a high temperature to form an oxidized titanium film; 3) synthesizing hydroxyapatite by using a wet method, and sintering, crushing and sieving the hydroxyapatite to obtain powder; 4) preparing a thin hydroxyapatite coat on the oxidized titanium film by using plasma spraying technology; and 5) putting the hydroxyapatite coat product in a container, and drying the treated product by using water vapor to obtain the hydroxyapatite coat/surface activated titanium-based composite coat. The process is simple; when an obtained coat compound implanted material is implanted to the human body, the material plays a role in bone bridge connection of the hydroxyapatite at the early stage, provides rich calcium and phosphorus elements for bone growth, accelerates the growth of a new bone, and shortens an operation healing stage; and when the hydroxyapatite coat is basically degraded, the bone texture and the metal surface form a direct chemical bond combination.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a method for preparing a hydroxyapatite coating / surface-activated titanium-based composite coating using a surface activation modification method of titanium and titanium alloys and a plasma spraying surface coating composite technology Preparation. Background technique [0002] Hydroxyapatite (HA) is the main inorganic part of human teeth and bone tissue. It has excellent biocompatibility and can form a direct chemical bond with bone and soft tissue. Therefore, hydroxyapatite ceramics are widely used in bone defects. filling etc. However, like most ceramic materials, the brittleness of bulk hydroxyapatite ceramics and its fatigue failure in the physiological environment can only be used for bone repair and replacement without bearing or only under pressure, and cannot be used as a bearing. The material is used clinically. Metals have excellent mechanical properties and hav...

Claims

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Application Information

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IPC IPC(8): A61L27/32A61L27/06
Inventor 曹阳朱容李开绵蒋盛军王江吴溢文曹献英庞素娟
Owner HAINAN UNIVERSITY
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