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Method for treating kidney disorders

A technology for effective treatment of chronic kidney disease, applied in chemical instruments and methods, pharmaceutical formulations, medical preparations containing active ingredients, etc.

Active Publication Date: 2021-06-08
UNIV OF MIAMI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such treatments merely slow the loss of kidney function or manage blood pressure and do not treat or prevent other effects of the disease

Method used

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  • Method for treating kidney disorders
  • Method for treating kidney disorders
  • Method for treating kidney disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0047] This example demonstrates that administration of APOM to a clinically relevant in vivo model of Alport syndrome prevents renal failure, as well as abnormal lipid content in the renal cortex.

[0048] Materials and methods:

[0049] Construction and use of human recombinant APOM protein : The protein was purchased from Sino Biological (13495-H02H). The DNA sequence encoding human APOM protein (O95445) (Met 1-Asn 188) was fused at the C-terminus to the Fc region of human IgG1. The resulting human recombinant APOM protein was found to be >85% pure as determined by SDS-PAGE and had an endotoxin concentration of <1.0 EU per μg of protein as determined by the LAL method.

[0050] deployment : Proteins were lyophilized from sterile PBS (pH 7.4) and typically 5%-8% trehalose, mannitol and 0.01% Tween 80 were added as protectants before lyophilization. Specific concentrations are included in the hard copy of each COA. For injection, sterile water is added to vials to prep...

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Abstract

Disclosed herein is a method of treating or preventing renal disease in a subject suffering from Alport Syndrome, as well a method of treating or preventing chronic kidney disease. The method comprises administering to a subject in need thereof an effective amount of human apolipoprotein M.

Description

technical field [0001] The present disclosure relates to materials and methods for treating chronic kidney disease and nephropathy in subjects with Alport Syndrome. [0002] Cross-references to related applications and electronically filed materials are incorporated by reference [0003] This application claims the benefit of U.S. Provisional Patent Application No. 62 / 697,556, filed July 13, 2018, which is hereby incorporated by reference in its entirety. [0004] The Sequence Listing, which is part of this disclosure, is filed simultaneously with the specification as a text file. The name of the text file containing the sequence listing is "53188_Seqlisting.txt". The sequence listing was created on July 2, 2019, and is 4,142 bytes in size. The subject matter of the Sequence Listing is incorporated herein by reference. Background technique [0005] Alport syndrome is an inherited disorder caused by mutations in the three type IV collagen genes, COL4A3, COL4A4, and COL4A5...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K38/02A61K38/17A61P13/12C07K14/775
CPCA61P13/12C07K14/775A61K38/1709
Inventor A·富尔诺尼S·默谢尔
Owner UNIV OF MIAMI
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