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A preparation and recurrence risk model for judging the prognosis of early endometrial cancer

A technique for endometrial cancer and prognosis, applied in the field of judging the prognosis of early endometrial cancer, in the field of biomedicine, can solve the problem of unclear relationship between molecular typing and prognosis of endometrial cancer, and achieve a low and high risk of recurrence. The effect of predictive power

Active Publication Date: 2022-07-01
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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AI Technical Summary

Problems solved by technology

However, the relationship between immune checkpoint VISTA endometrial cancer molecular typing and prognosis is still unclear. Whether VISTA combined with molecular typing can be used to judge the prognosis of early endometrial cancer remains to be developed.

Method used

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  • A preparation and recurrence risk model for judging the prognosis of early endometrial cancer
  • A preparation and recurrence risk model for judging the prognosis of early endometrial cancer
  • A preparation and recurrence risk model for judging the prognosis of early endometrial cancer

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Embodiment

[0080] 1. Research objects

[0081] The research object of this case is the tumor tissue specimens of patients with FIGO stage I–II endometrial cancer after surgery. Inclusion criteria: definite pathological diagnosis of endometrial cancer; FIGO stage I–II; complete pathological sections and paraffin specimens; follow-up time of at least 3 months; complete clinical data.

[0082] Exclusion criteria: FIGO stage III–IV; preoperative neoadjuvant chemotherapy; preoperative radiotherapy; combined ovarian cancer, cervical cancer and other gynecological malignancies; no tumor tissue in surgical specimens after curettage; absence of pathological sections or paraffin specimens; The follow-up time was less than 3 months.

[0083] 2. Research methods

[0084] 1. Collection of clinical data

[0085] By reviewing the patient's inpatient medical records and outpatient medical records, record the patient's age, surgical method, ascites cytology results, whether he received chemotherapy be...

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Abstract

The invention relates to a preparation and a recurrence risk model for judging the prognosis of early endometrial cancer. The present invention judges the POLE mutation status by sequencing, detects the mismatch repair protein, p53 and VISTA in 4 by immunohistochemical method, and judges the histological grade and immunohistochemical result of the tumor by observing under a microscope, so as to determine the molecular classification of endometrial cancer. Type, tumor grade, and expression of VISTA, and then assign a risk score, 0 for POLE mutation, 1 for dMMR and NSMP, and 2 for p53 in molecular typing; 0 for VISTA-positive and 1 for VISTA-negative 1 point for high-grade tumors and 0 for low-grade tumors. The overall risk score is the sum of the three above-mentioned scores, and the total score ranges from 0 to 4: 0–1 as low risk, 2 as intermediate risk, and 3–4 as high risk. The model can effectively predict the recurrence and death risk of early stage (FIGO I and II) endometrial cancer, so as to avoid over-treatment and under-treatment, and achieve the purpose of precise treatment and individualized treatment.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the field of judging the prognosis of early-stage endometrial cancer. Background technique [0002] Endometrial cancer is a common malignant tumor of female reproductive tract in my country, and the age of onset shows a younger trend. In 2015, there were about 63,000 new cases of endometrial cancer in my country, and about 22,000 deaths. Since abnormal vaginal bleeding is the most common symptom of endometrial cancer, 70–80% of patients are diagnosed with early-stage endometrial cancer, namely FIGO stages I and II. Surgery is the main treatment for patients with early-stage endometrial cancer. Those with high risk of postoperative recurrence should receive adjuvant therapy such as combined therapy and chemotherapy. The choice of postoperative adjuvant therapy is mainly based on the pathological results of surgery and the stage of surgery. Currently the most widely used in clinical p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886G01N33/68G01N33/574G16B20/50G16B25/00
CPCC12Q1/6886G01N33/68G01N33/57442G01N33/57484G16B20/50G16B25/00C12Q2600/118C12Q2600/112C12Q2600/156G01N2333/70532G01N2333/68G01N2333/4748G01N2333/47
Inventor 于双妮宗丽菊陈杰向阳卢朝辉曹冬焱杨隽钧常晓燕姜英李冬梅贾丛伟周娜
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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