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A prognostic evaluation system for endometrial cancer incorporating molecular typing and immune scoring

An evaluation system and molecular typing technology, applied in the field of biomedicine, can solve the problems of long time, limited application of molecular typing, and high economic cost, and achieve the effect of high repeatability and concise MIP risk typing.

Active Publication Date: 2022-03-22
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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Problems solved by technology

[0006] TCGA endometrial cancer molecular typing is proposed based on high-throughput deep sequencing. High-throughput sequencing has high economic costs and takes a long time, which will limit the clinical application of molecular typing.
Although the TCGA alternative typing scheme proposed by later scholars has been proved to be effective by multiple teams, neither the TCGA typing nor the alternative typing can effectively distinguish the prognosis of 60%–70% of dMMR types and NSMP

Method used

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  • A prognostic evaluation system for endometrial cancer incorporating molecular typing and immune scoring
  • A prognostic evaluation system for endometrial cancer incorporating molecular typing and immune scoring
  • A prognostic evaluation system for endometrial cancer incorporating molecular typing and immune scoring

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Embodiment

[0068] 1. Research object

[0069] The research object of this implementation case is the postoperative tumor tissue specimens of patients with FIGO I-III endometrial cancer. Inclusion criteria: clear pathological diagnosis of endometrial cancer; FIGO I-III stage; complete pathological sections and paraffin specimens; follow-up time of at least 3 months; complete clinical data.

[0070] Exclusion criteria: FIGO stage IV; preoperative neoadjuvant chemotherapy; preoperative radiation therapy; combined with ovarian cancer, cervical cancer and other gynecological malignancies; no tumor tissue in surgical specimens after curettage; missing pathological sections or paraffin specimens; follow-up time less than 3 months.

[0071] 2. Research methods

[0072] 1. Collection of clinical data

[0073] By reviewing the patient's inpatient medical records and outpatient medical records, record the patient's age, operation method, ascites cytology results, whether to receive chemotherapy ...

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Abstract

The present invention is an endometrial cancer prognosis evaluation system (MIP score) based on molecular typing, immune scoring and pathological morphological diagnosis, which is used to determine the prognosis of endometrial cancer. Sequencing was used to determine POLE mutation status and immunohistochemistry was used to detect 4 mismatch repair proteins and p53 to determine molecular classification. Immunohistochemistry was used to detect the expression of VISTA in tumor stromal immune cells and perform immune scoring. The histological grade and lymphovascular space invasion (LVSI) of the tumor were determined by observing the pathological morphology under the microscope. Recurrence risk scores were assigned respectively. This prognostic evaluation system can effectively distinguish the risk of recurrence and death of endometrial cancer.

Description

Technical field [0001] The present invention relates to the field of biomedicine, and in particular to the prognosis of endometrial cancer. Background technique [0002] Endometrial cancer is a common gynecological malignant tumor. Its incidence rate in my country is about 60 / 100,000, and its mortality rate is about 20 / 100,000. The incidence rate is on the rise. In 2015, there were more than 60,000 new cases and more than 20,000 deaths in China. The most common treatment method for endometrial cancer is surgery. According to the postoperative pathology report, those with high-risk factors are combined with postoperative brachytherapy or pelvic external radiotherapy or adjuvant therapy such as chemotherapy. Pathological diagnosis is the main basis for postoperative adjuvant treatment. The 2014 edition of the "WHO Histological Classification of Tumors of Female Reproductive Organs" divides endometrial cancer into nine categories, namely endometrioid carcinoma, serous carcino...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886G01N33/574
CPCC12Q1/6886G01N33/57442G01N33/57484C12Q2600/118C12Q2600/112C12Q2600/156C12Q2600/158G01N2333/4748
Inventor 陈杰宗丽菊卢朝辉于双妮向阳曹冬焱杨隽钧李霁李媛毛歆歆李冬梅周娜
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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