A kind of ribavirin particle and preparation method thereof

A technology of ribavirin and granules, applied in the field of drug preparation, can solve the problems of decreasing drug amount, affecting drug efficacy, affecting curative effect, etc., and achieving the effects of average release and absorption speed, rapid and sufficient dissolution, and uniform particle shape and stability.

Active Publication Date: 2022-06-10
药大制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Although ribavirin has good water solubility, if it is made into granules and is not sufficiently stirred during brewing, precipitation will easily occur. If the precipitated drug is not taken, the amount of drug ingested will decrease, which will affect the curative effect
In order to increase the dissolution rate of granules, patients often use higher temperature water to brew, and then let it stand for cooling, which will easily affect the efficacy of the medicine

Method used

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  • A kind of ribavirin particle and preparation method thereof

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Abstract

The invention belongs to the field of medicine preparation, and specifically relates to a ribavirin granule and a preparation method thereof, comprising ribavirin and an active filler, and the active filler includes a water-insoluble activated carbon material and a water-soluble small molecule filler agent. The ribavirin granules prepared by the preparation method of the present invention have fast melting speed, are easy to brew, and have uniform granules, small particle diameters and are easy to absorb.

Description

A kind of ribavirin granule and preparation method thereof technical field The invention belongs to the field of medicine preparation, be specifically related to a kind of ribavirin granule and preparation method thereof. Background technique The water solubility of ribavirin is good, and oral absorption is fast, and is very good for the indications that need to be administered as soon as possible However, it has a large first-pass effect after oral administration and is prone to toxic side effects. Ribavirin has many adverse effects in clinical trials. Reaction, if it is handled improperly, it is easy to cause danger. The general method to ensure the efficacy of the drug and reduce the side effects is to take it several times a day. During the actual operation, patients are prone to the situation that the number of mixing times and the interval time are too short or too long, which increases the reduction of curative effect and production. risk of more serious adver...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K47/04A61K47/36A61K47/10A61K31/7056
CPCA61K9/1611A61K9/1623A61K9/1652A61K9/1682A61K31/7056
Inventor 郝静梅朱靓
Owner 药大制药有限公司
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