Single-sample ceRNA network identification method and device, electronic equipment and storage medium

Abstract

The invention provides a single-sample ceRNA network identification method and device, electronic equipment and a storage medium, and relates to the technical field of gene identification. The single-sample ceRNA network identification method comprises the following steps: identifying and acquiring a plurality of ceRNA competition relation pairs corresponding to each sample in matched samples according to a transcriptome matrix of miRNA of the matched samples, transcriptome matrixes of a first target gene and a second target gene of the matched samples and priori miRNA and target gene regulation and control relation data; and fusing the plurality of ceRNA competition relationship pairs corresponding to each sample to obtain a ceRNA network corresponding to each sample. According to the method, the ceRNA network of the single sample is obtained based on the miRNA of the matched sample, the transcriptome matrix of the first target gene and the transcriptome matrix of the second target gene and the regulation and control relation data of the priori miRNA and the target genes, the gene regulation and control mechanism in the single sample can be disclosed, and the competitive relation between the miRNA target genes under the single sample can be reflected.

Description

technical field [0001] The present invention relates to the technical field of gene identification, in particular to a single-sample ceRNA network identification method, device, electronic equipment and storage medium. Background technique [0002] Micro Ribonucleic Acid (miRNA) is a kind of non-coding conservative small ribonucleic acid (Ribonucleic Acid, RNA) molecule. It usually negatively regulates protein-coding gene mRNA (MessengerRNA) to regulate gene expression levels. Although miRNA is a small molecule, it plays an important role in many biological processes. The Competing Endogenous RNA (ceRNA) hypothesis reveals that different RNA transcripts compete with each other to bind to miRNA. These competing RNA transcripts are collectively referred to as ceRNA, and mainly include four categories: protein-coding gene mRNA, long-chain non-coding RNA (lncRNA), pseudogene transcript (pseudogene) and circular RNA (circRNA). The competition network is ceRNA network. Previou...

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Problems solved by technology

[0004] However, existing methods do not consider miRNA transcriptome data

However, the ceRNA network is closely related to the miRNA transcriptome data, so the obtained ceRNA network cannot accurately reflect the competitive relationship between miRNA target genes in a single sample.

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