Hollow metal microneedle array, preparation method, transdermal drug delivery patch and injection syringe needle

Abstract

The invention discloses a hollow metal microneedle array, a preparation method of the hollow metal microneedle array, a transdermal drug delivery patch and an injection syringe needle. The hollow metal microneedle array comprises a substrate, a plurality of metal capillary tubes and structural adhesive, wherein a groove is formed on the surface of the same side of the substrate; multiple pairs of through positioning grooves are formed on two side walls of the groove; and the multiple pairs of positioning grooves are arranged along the length direction of the substrate according to a set interval and are in mutual parallel; the plurality of metal capillary tubes are arranged in the multiple pairs of positioning grooves in a one-to-one correspondence mode; one end of the same side of each of the plurality of metal capillary tubes is the syringe needle and extends out of the substrate so as to form a syringe needle array, and the syringe needles in the same row in the syringe needle array are provided with main inclined surfaces in the same direction; and the structural adhesive is coated in the groove and the multiple pairs of positioning grooves to be cured so as to fix the plurality of metal capillary tubes on the substrate. According to the hollow metal microneedle array, all microneedles can be punctured into the skin conveniently, no pain is caused, the drug loading capacity of a single microneedle is large, the structure is firm and reliable, machining is easy, and cost is low.

Description

[0001] Cross References to Related Applications [0002] This application is based on the Chinese patent application with application number: 202011260037.X and the filing date is November 12, 2020, and claims the priority of this Chinese patent application. The entire content of this Chinese patent application is hereby incorporated into this application Reference. technical field [0003] The invention relates to the technical fields of medical equipment and medicine, in particular to a hollow metal microneedle array and a preparation method, a transdermal drug delivery patch and an injection needle. Background technique [0004] Microneedle array is the core component of microneedle transdermal drug delivery patch and microneedle array injection device, which is composed of many thin and short microneedles arranged at certain intervals and fixed on the substrate. Microneedle transdermal drug delivery patches are usually pre-managed to immobilize tiny doses of drugs on th...

AI Technical Summary

Problems solved by technology

There are two main types of microneedle arrays used for microneedle transdermal drug delivery patches: the first type, microneedles and their fixed substrates are made of single crystal silicon or plastic, metal and other single materials through photolithography, etching, The solid microneedle arrays formed by injection molding or laser cutting and other processes are integrated, but how to quantitatively, uniformly and reproducibly fix various drugs on all the needle tips of these solid microneedle arrays is not easy. In the process of piercing the stratum corneum, how to ensure that the microneedle will not break and the drug on the needle tip can penetrate intact and not fall off in vitro will face severe challenges; the second type, the microneedle and the substrate are composed of two different Assembled with materials, such as patent documents CN101829396A, CN101912663A, etc., but to manufacture this combined structure, on the one hand, it is required to be able to quickly separate, clamp, transport, arrange and accurately position a large number of thin and short microneedles. Manipulation and control, on the other hand, must ensure sufficient fixing strength between the microneedle and the very thin substrate, which is extremely difficult and costly to realize, and has not yet been automated and mass-produced

Existing microneedle arrays usually consist of dozens to hundreds of microneedles arranged in an array of N×M. Compared with soft skin, the substrate used to fix the microneedles is usually much harder; Because the height of the microneedles of the substrate is generally only a few hundred microns, it is bound to cause that only the microneedles located at the edge of the substrate can actually penetrate the stratum corneum, so it is impossible to transport the drugs on the many microneedles located in the middle of the substrate. lead to uncertainty in dosing

In addition, patients themselves cannot further divide the existing microneedle array structure according to the needs of the actual dosage, which will undoubtedly greatly limit the doctor's ability to choose the dosage according to the patient's condition, age and administration site (microneedle array structure). The flexibility of the number of needles or the area of ​​the array); at the same time, because there are a wide variety of drugs suitable for microneedle administration and their characteristics and dosages vary greatly, the problem that the structure of the microneedle array is difficult to divide by itself will inevitably greatly limit The application flexibility of existing microneedle array specifications and varieties makes it difficult to become a universal carrier suitable for various drugs, thus bringing great benefits to microneedle array manufacturers and the manufacture, application and popularization of microneedle drug delivery patches for various drugs. come very difficult

Finally, the microneedle array injection device injects a small dose of injection solution into the patient's body through the needles of the hollow microneedle array piercing the skin. The hollow microneedle array is usually a two-dimensional array fixed on the same substrate, such as Patent document CN101912663A, it is difficult to manufacture in batches and the cost is high

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