Application of fructus ulmi in preparation of medicine for treating hepatic fibrosis

A technology of liver fibrosis and liver fibrosis, applied in the field of liver fibrosis drugs, can solve the problems of ineffective treatment of liver fibrosis and achieve the effect of reducing liver fibrosis score

Active Publication Date: 2022-05-17
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are currently no effective drug

Method used

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  • Application of fructus ulmi in preparation of medicine for treating hepatic fibrosis
  • Application of fructus ulmi in preparation of medicine for treating hepatic fibrosis
  • Application of fructus ulmi in preparation of medicine for treating hepatic fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] The present invention will be described in further detail below in conjunction with specific embodiments.

[0021] Embodiment prepares the aqueous ethanol extract of turnip

[0022] Take 500 g of turnip powder, extract 5 times with 500 mL of 75% ethanol aqueous solution, combine the extracts, and spin-evaporate under reduced pressure at room temperature until there is no liquid, and then grind and pulverize the obtained solid.

[0023] The extract powder is directly used in animal experiments.

[0024] Animal experiment

[0025] 1. Animal handling process

[0026] 30 BALB / c mice (6-7 weeks old, 6 spare) were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. Upon arrival, animal house personnel transferred the animals from their shipping packages to their cages and inspected each animal. The scope of inspection includes appearance, limbs and cavities, etc., and whether there are any abnormalities when the animal is stationary or moving. T...

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Abstract

The invention belongs to the field of hepatic fibrosis medicines. Aiming at the problem that no medicine for effectively treating hepatic fibrosis exists at present, the invention provides application of fructus ulmi in preparation of the medicine for treating hepatic fibrosis. The preparation method of the ulmus macrocarpa hance extract comprises the following steps: extracting ulmus macrocarpa hance powder with an ethanol aqueous solution, and carrying out reduced pressure rotary evaporation until no liquid exists, so as to obtain the ulmus macrocarpa hance hance ethanol aqueous solution extract. Animal experiments show that the ulmus macrocarpa hance extract can significantly reduce the hepatic fibrosis score (plt; 0.05), and a new choice is provided for preparing the medicine for treating the hepatic fibrosis.

Description

technical field [0001] The invention belongs to the field of liver fibrosis drugs, and in particular relates to the application of Chinese catkins in the preparation of drugs for treating liver fibrosis. Background technique [0002] Liver fibrosis is a pathophysiological process, which refers to the abnormal proliferation of connective tissue in the liver caused by various pathogenic factors. Any liver injury has a process of liver fibrosis in the process of liver repair and healing. If the damage factors cannot be removed for a long time, the fibrosis process will develop into liver cirrhosis if it continues for a long time. Therefore it is not an independent disease. There are many etiologies of liver fibrosis, among which viral hepatitis, alcoholic liver, fatty liver, and autoimmune diseases are common clinically. Anti-hepatic fibrosis treatment mainly includes: removing pathogenic factors for the primary disease, such as anti-hepatitis B, hepatitis C virus treatment, ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/16
CPCA61K36/185A61P1/16A61K2236/333A61K2236/53Y02A50/30
Inventor 姜曼王舒瑶
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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