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Device and method for cooling brain and diagnosing and treating glioblastoma

A technology of the brain and cerebellum, applied in the field of devices and methods for cooling the brain and diagnosing and treating glioblastoma, capable of solving brain tissue stroke and other problems

Pending Publication Date: 2022-07-08
黄立臻
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although cardiopulmonary resuscitation (CPR) is already the standard treatment for cardiac arrest, even successful cases can result in strokes of brain tissue with significant disability

Method used

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  • Device and method for cooling brain and diagnosing and treating glioblastoma
  • Device and method for cooling brain and diagnosing and treating glioblastoma
  • Device and method for cooling brain and diagnosing and treating glioblastoma

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Experimental program
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Embodiment Construction

[0045] Animal research:

[0046] Due to ineffective previous attempts to cool the brain via lumbar puncture, the cisterna magna, located at the base of the brain, was chosen as the entry point for the cooling device. Entry through the spinal canal leads to an increase in the temperature of the aCSF due to the warmth of the circulatory vessels in the spinal canal. With access to the maximal cistern, the cerebellomedullary cistern, a 17-gauge needle can be placed in the subarachnoid space and used to circulate cooled saline out through a drain in the forehead. Using this approach, initial work on more than 50 recently deceased pigs provided promising results and encouraged in vivo testing.

[0047] For in vivo testing, our approach was combined with thermistors placed at different depths of the brain (5mm increments) to monitor the temperature of the tissue, and therefore monitoring such as Figure 24 The effect of circulatory cooling of aCSF as depicted in the CT scan. Brain...

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Abstract

A method and apparatus for preventing brain death by using rapid and safe cooling of the brain is disclosed. A needle / cannula allows cooled artificial cerebrospinal fluid (aCSF) to flow around the brain by accessing a cerebellar medullary pool having access through the patient's neck with a specially designed needle / cannula, accessing the cerebellar medullary pool through the patient's neck, and circulating the cooled artificial cerebrospinal fluid (aCSF) around the space within the brain and in the subarachnoid space around the brain. The aCSF exits from an opening in the skull in which the temperature / pressure sensor is placed. The data is sent to a computer-controlled motorized system that pumps the cooled aCSF to a needle / cannula placed in the cerebellar medulla oblongata cell. Pumping of the aCSF is controlled to maintain a predetermined temperature and / or pressure of the outlet aCSF.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims priority under 35 USC 119 to US Provisional Patent Application Serial No. 62 / 905,996, filed on September 25, 2019, which is incorporated herein by reference. technical field [0003] The illustrated embodiment is directed to a unique approach to safely and rapidly rapidly cool the brain to deep hypothermia (20°C to 25°C using artificial cerebrospinal fluid (aCSF) cooled to 1-10°C) with In the prevention of brain death in the absence of blood circulation to the brain, including diseases such as cardiac arrest due to myocardial infarction, stroke, and bleeding. Background technique [0004] Fifty years ago, Professor Robert White demonstrated that when all major blood vessels in the neck are tied, cooling the monkey's brain to 15 degrees Celsius will protect the brain without blood circulating to the brain for an hour. The structure and function of the brain. When the bandages around all neck blo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F7/12
CPCA61F7/12A61B8/12A61B8/0808A61B8/445A61M2039/025A61M39/0247A61M2039/0276A61M2205/3368A61F2007/0063A61F2007/0086A61F2007/126A61M2205/0266A61M2205/058A61M2205/3344A61M5/1723A61M2005/1726A61M2205/3606A61F2007/0002A61F2007/0069A61F2007/0096A61B17/34
Inventor 黄立臻罗马·索莱克约翰·弗斯
Owner 黄立臻
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