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Use of thiazolidinedione for preventing or retaining non-insulin-dependent diabets mellitus (MIDDM) attack

An insulin-dependent technology, applied in diseases, urinary system diseases, metabolic diseases, etc., can solve problems not mentioned

Inactive Publication Date: 2005-05-25
DAIICHI SANKYO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In the aforementioned patent documents there is no mention of the use of the compounds identified in the present application for the treatment of patients with impaired glucose tolerance in order to prevent or delay the onset of NIDDM and the complications caused by it

Method used

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  • Use of thiazolidinedione for preventing or retaining non-insulin-dependent diabets mellitus (MIDDM) attack
  • Use of thiazolidinedione for preventing or retaining non-insulin-dependent diabets mellitus (MIDDM) attack
  • Use of thiazolidinedione for preventing or retaining non-insulin-dependent diabets mellitus (MIDDM) attack

Examples

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Embodiment 1

[0219] In a previously unknown, randomized outpatient trial, the test compound (+)-5-[[4-[(3,4-dihydro-6- Hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione (troglil Ketones) on glucose tolerance and insulin sensitivity were compared with placebo. The trial on impaired glucose tolerance (IGT) included a 2-week screening period and a 12-week treatment period. Fifty-six patients were randomized to treatment with placebo or 400 mg / day troglitazone. Oral glucose tolerance test (OGTT) and frequently sampled intravenous glucose tolerance test (FSIGTT) were performed before drug treatment and after 6 and 12 weeks of randomized treatment to determine insulin sensitivity.

[0220] The patients involved in this study were reasonably healthy adults, and their IGT was expressed by OGTT according to the World Health Organization (WHO) standard (Harris M.I., Hadden W.C., Knowler W.C., Berrett P.H., International Criteria for the Diagnosis of Diab...

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Abstract

A novel method of using thiazolidinedione derivatives and related antihyperglycemic agents to treat populations experiencing impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus (NIDDM) and complications arising therefrom is disclosed.

Description

technical field [0001] The present invention relates to compounds which can be used to treat impaired glucose tolerance to prevent or delay the onset of non-insulin dependent diabetes mellitus (NIDDM). More specifically, the present invention relates in one embodiment to the administration to a patient of certain known thiazolidinedione derivatives and related antihyperglycemic agents which reduce fasting insulin concentrations and restore normal glucose tolerance in humans , thereby preventing or delaying the onset of NI DDM or the complications caused by it. Background technique [0002] Diabetes is one of the most prevalent chronic diseases worldwide, with considerable personal and financial burdens on patients, their families and society. There are different types of diabetes with different etiologies and pathogens. For example, diabetes is a disorder of carbohydrate metabolism characterized by hyperglycemia and glucosuria, resulting from insuffic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/44A61K31/426A61K31/425A61P3/10C07D277/20A61K31/41A61K31/42A61K31/421A61K31/423A61K31/427A61K31/4439A61K31/495A61K31/505A61P3/06A61P3/08A61P5/50A61P9/12A61P13/02A61P15/00A61P25/02A61P43/00C07D263/44C07D263/56C07D277/34C07D291/04C07D413/14C07D417/06C07D417/10C07D417/12
CPCA61K31/41A61K31/42A61K31/425A61K31/426A61K31/427A61K31/44A61K31/4439A61K31/495A61K31/505A61P13/02A61P15/00A61P25/02A61P3/06A61P3/08A61P43/00A61P5/50A61P9/12A61P3/10
Inventor J·奥列夫斯基T·安东努齐D·罗克伍德R·诺里斯
Owner DAIICHI SANKYO CO LTD
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