105 results about "Antihyperglycemic Agents" patented technology

The invention discloses a preparation method of a cocoon sericin layer alcohol soluble substance, comprising the following steps: wetting clean cocoon shell, cocoon outer floss, waste silk or raw silk in water and carrying out degumming treatment for 1-5h under the conditions that the temperature is 110-140 DEG C and the pressure is 0.1-0.26Mpa to obtain silk degumming liquid; filtering and concentrating the silk degumming liquid to obtain concentrated sericin liquid and then adding an organic solvent for extraction; collecting supernatant and repeatedly extracting lower precipitate with the organic solvent; carrying out spray drying or vacuum freeze drying after concentrating combined supernatant to prepare powder, namely the cocoon sericin layer alcohol soluble substance; wherein, the volume ratio of the concentrated sericin liquid to the organic solvent is 1:1-9. The non-sericin component obtained by the invention has antioxidant activity, antityrosinase activity and alpha-glucosidase inhibition activity, and has wide application prospects in such aspects as cosmetics, anti-aging health care products, hypoglycemic drugs and the like.

The present invention relates to novel sulfoxide and bis-sulfoxide compounds, compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

The invention discloses a mulberry active phenolic compound and a pollution-free extraction and purification method thereof. The method comprises the steps that microwave and vapor high temperature instantaneous enzyme deactivation is carried out on fresh mulberries in sequence, then mechanical crushing, centrifugal layering, food grade acidified alcohol extraction, vacuum concentration and ultrafiltration membrane purification are carried out, and therefore a mulberry phenolic compound extracting solution with the biological activity is obtained. An organic reagent with the low concentration is adopted, mulberry crushing and phenolic compound extraction and purification are achieved under the mild condition, and the natural character and biological activity of the mulberry phenolic compound can be maintained. Compared with a conventional extraction method, the mulberry extracting solution has the higher-concentration total phenol and total anthocyanins, the extraction solution has the good color and luster and high oxidation resistance, alpha-glucosidase enzymatic inhibitory activity and food safety, and the mulberry active phenolic compound can be used as a safety raw material of antioxidant and hypoglycemic drug and health care product development. The conditions are mild, operation is convenient, and industrial production of high-activity natural products is facilitated.

Bougainvillea glabra triterpenoid saponin compounds comprise a triterpenoid saponin with a skeleton containing oleanolic acid, wherein the 3-site of the oleanolic acid is connected with 1'-site of beta-D-pyran glucuronic acid by an oxygen atom, and comprise other two derivates with the same skeleton structure; and the compound as shown in formula (I) is preferable, in the formula (I), R1 is methyl or hydrogen and R2 is hydrogen or beta-D-pyran xylose. The bougainvillea glabra triterpenoid saponin compounds 1-3 are new plant sourced hypoglycemic drugs. Pharmaceutical compositions with the compounds as active ingredients and a preparation method and application thereof in making the hypoglycemic drugs are provided.

A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient.Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and / or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and / or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diseases or syndrome X.

The invention relates to application of an extract of oak tree leaves in preparation of a medicament for preventing and treating high blood sugar disease. The invention provides a preparation method for separating the extract from the oak tree leaves. Pharmacological experiments prove that the extract has obvious effect of reducing blood sugar. The invention also provides application of the extract in preparing a medicinal preparation for preventing and treating diabetes.

The present invention provides novel substituted chalcone derivatives which exhibit anti-hyperglycemic and anti-dyslipedemic activity. The invention also provides a method for treating type II diabetes and associated hyperlipidemic conditions in a mammal by administering the compounds of the present invention and compositions containing these derivatives.

The invention discloses use of bacillus coagulans JA845 in preparing an enzyme activity inhibitor with a hypoglycemic function and relates to the field of hypoglycemic drugs. The bacillus coagulans JA845 is prepared into a fermentation supernatant, a cell-free extract and a bacterial cell metabolite, activity inhibition rates of the bacillus coagulans JA845 to alpha-glucosidase and DPP-4 are measured. Results show that a to-be-detected sample of the bacillus coagulans JA845 has an activity inhibition effect on the alpha-glucosidase and the DPP-4, the cell-free extract of the bacillus coagulans JA845 had the highest inhibition activity, such that the bacillus coagulans JA845 and / or derivatives thereof can be used for preparing the activity inhibitor of the alpha-glucosidase and the DPP-4 and a new thought is provided for preparing hypoglycemic drugs.

The invention belongs to the technical field of medicines, and particularly relates to an application of a frankincense pentacyclic triterpenic acid compound, pharmaceutically acceptable salt and combination containing the compound or the salt to preparation of a diabetes treating medicine. The compound and the combination thereof or the salt shows good blood glucose reducing functions for different insulin diabetes resistance animal models, and can possibly serve as an insulin sensitizing agent blood glucose reducing medicine for overcoming limitation of an existing medicine.

The invention discloses an extraction method and application of phenanthrene compounds from the overground part of Chinese yam, belonging to the technical field of separation and application of the active components of the overground part of Chinese yam. According to a technical scheme in the invention, the method comprises the following main steps: subjecting the coarse powder of the overground part of Chinese yam to percolation and extraction with ethanol and then carrying out concentration; then extracting extract obtained in the previous step with an organic solvent; and then carrying out separation by using macroporous adsorption resin, gel and Sephadex column chromatography and other column chromatography so as to obtain the phenanthrene compounds. Four phenanthrene compounds extracted from the overground part of Chinese yam all show substantial inhibitory activities to alpha-glucosidase, and the activities are all better than the activity of the hypoglycemic agent acarbose under same conditions.

The application belongs to the technical field of medicament synthesis, and particularly relates to an oleanolic acid derivative, a preparation method and application thereof. The invention claims theoleanolic acid derivative which is as shown in general formula (I), or a corresponding isomer, a non-corresponding isomer, medically acceptable salt, prodrug and active metabolite, and a mixture thereof, wherein R is selected from an aryl or heteroaryl which is optionally substituted by any one or more groups of a hydrogen atom, X, alkyl, substituted alkyl, alkoxyl or heteroaryl. The oleanolic acid derivative is obtained by performing chemical modifying on a natural product oleanolic acid serving as a lead compound, and is novel in structure, high in bioavailability and high in bioactivity. In vitro pharmacological experiments show that the oleanolic acid derivative is a noncompetitive alpha-glucosidase inhibitor, which has an obvious effect on inhibiting the activity of the alpha-glucosidase inhibitor; the activity of the oleanolic acid derivative is far higher than that of a positive drug, namely, acarbose, and has a very upbeat prospect in the application of a hypoglycemic drug.

The invention provides 2,6-epoxydiphenylheptane compounds and a preparation method and application thereof, and pharmaceutical compositions and application thereof, belonging to the technical field ofdrug preparation. The 2,6-epoxydiphenylheptane compounds provided by the invention mainly include tsaokopyranol compounds with 13 structures, and the compounds have obvious inhibitory activity on alpha-glucosidase, can form pharmaceutical compositions with a medicinal carrier or an excipient, and can be used for preparing alpha-glucosidase inhibitor drugs, hypoglycemic drugs or health-care food.