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Chinese medicament for reducing blood sugar and preparation method thereof

A technology for lowering blood sugar and drugs, which is applied in the field of research and development of new traditional Chinese medicines, and achieves the effect of low cost and simple preparation process

Active Publication Date: 2010-11-24
周亚伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Recently, based on the receptor theory, the United States has developed a third-generation drug for treating diabetes—troglitazone. According to current reports, the long-term curative effect is stable, but it has certain side effects and has not yet been widely promoted.

Method used

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  • Chinese medicament for reducing blood sugar and preparation method thereof
  • Chinese medicament for reducing blood sugar and preparation method thereof
  • Chinese medicament for reducing blood sugar and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: the preparation method of oak leaf effective component

[0030] Weigh 5 kg of medicinal materials, extract the medicinal materials with 10 times the amount of medicinal materials, reflux extraction three times, each time for 1 hour, combine the three extracts, filter the extracts, concentrate to dryness, and obtain 210 g of samples. After the sample is dissolved, perform the α-naphthol test (Molish) reaction: take 1ml of the solution, add 1 drop of 10% α-naphthol alcohol solution, shake well, slowly add concentrated H along the tube wall 2 SO 4 10 drops, without shaking, observe that there is a purple cup between the two liquid interfaces, indicating the presence of sugars and glycosides; use TLC (thin layer chromatography) to identify (developing agent: n-BuOH: HAc: H 2 O=4:1:5, V / V), dark spot at 254nm, FeCl 3Solution spraying, obvious dark blue spot; Embodiment 2: the preparation method of effective component of oak leaf

Embodiment 2

[0031] Weigh 5 kg of medicinal materials, extract the medicinal materials with 10 times the amount of medicinal materials and 95% ethanol, reflux extraction three times, each time for 1 hour, combine the three extracts, filter the extracts, concentrate to dryness, and obtain 143 g of samples. After the sample is dissolved, perform the α-naphthol test (Molish) reaction: take 1ml of the solution, add 1 drop of 10% α-naphthol alcohol solution, shake well, slowly add concentrated H along the tube wall 2 SO 4 10 drops, without shaking, observe the purple-red cup between the two liquid interfaces, indicating the presence of sugar and glycoside components; use TLC (thin layer chromatography) to identify (developing agent: CHCl 3 :MeOH=9:1, V / V)), there are dark spots at 254nm, sprayed with vanillin-sulfuric acid solution, and then heated, dark red spots appear.

Embodiment 3

[0032] Embodiment 3: the preparation method of oak leaf effective component

[0033] Weigh 5kg of medicinal materials, extract the medicinal materials with 10 times the amount of medicinal materials, reflux extraction three times, each time for 1 hour, combine the three extracts, filter the extracts, load the sample on 5kg of D101 macroporous resin, flow rate 15ml / min, After sample loading, eluted with water until the eluent was nearly colorless, shared 50 liters of water, eluted with 20% ethanol until the eluent was nearly colorless, eluted 40 liters, and eluted with 50% ethanol until the eluent was nearly Colorless, 40 liters were eluted, 80% ethanol was eluted until the eluate was nearly colorless, 30 liters were eluted, and finally 30 liters were eluted with 95% ethanol. Concentrate, dry, and collect samples. The sample weights obtained after concentration of each eluate were 2.60 g, 157.5 g, 22.40 g, 4.60 g and 3.7 g, respectively. After the sample is dissolved, perform...

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Abstract

The invention relates to application of an extract of oak tree leaves in preparation of a medicament for preventing and treating high blood sugar disease. The invention provides a preparation method for separating the extract from the oak tree leaves. Pharmacological experiments prove that the extract has obvious effect of reducing blood sugar. The invention also provides application of the extract in preparing a medicinal preparation for preventing and treating diabetes.

Description

technical field [0001] The invention belongs to the field of research and development of new traditional Chinese medicines. The invention relates to the preparation of hypoglycemic medicine by using traditional Chinese medicine and the preparation method thereof, especially relates to the preparation of the hypoglycemic medicine by obtaining effective components with hypoglycemic effect from the traditional Chinese medicine oak leaves by adopting modern extraction, separation and technology. Background technique [0002] Diabetes is a common disease. There are currently 150 million diabetic patients in the world, and it is predicted that the number of patients will increase to 333 million by 2025. TCM syndrome differentiation of diabetes belongs to the category of "diabetes" disease. Investigating its pathogenesis mainly lies in the loss of yin and fluid, excessive dryness and heat, and taking yin deficiency as the foundation and dryness and heat as the standard. Endogenous...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K36/718A61K36/8964A61P3/10A61K127/00
Inventor 周亚伟
Owner 周亚伟
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