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Preparation method and application of pH-sensitive plant microcapsule nano extruder

A technology of microcapsules and extruders, applied in the field of medicine, can solve the problems of frequent bioavailability and achieve the effect of simple preparation method

Active Publication Date: 2022-05-24
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Second, oral administration needs to overcome the intestinal mucus barrier and the epithelial cell barrier to enter the blood, which requires frequent doses or sustained bioavailability

Method used

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  • Preparation method and application of pH-sensitive plant microcapsule nano extruder

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] When the present invention is specifically implemented, a preparation method of a drug-loaded pH-sensitive plant microcapsule nano-extruder specifically includes the following steps:

[0022] 1) Weigh 20g of natural wild chrysanthemum pollen, dissolve it in 300ml of acetone, add it into a 1000ml round-bottomed flask, stir and reflux in an oil bath at 70°C for 12h, and filter the solution under vacuum after cooling to obtain the recovered pollen;

[0023] 2) Recover the pollen in step 1), dissolve it with 400ml 85% (w / w) phosphoric acid and add it to a 1000ml round-bottomed flask, stir and reflux for 12h in a 60°C oil bath, and the pollen solution is treated with phosphoric acid and then cooled and filtered, And successively wash with water, acetone, 2M HCl, 2M NaOH, water, acetone, 70% ethanol and suction filtration to obtain a suction filtration pollen;

[0024] 3) Filter the pollen with suction in step 2), dissolve it with 300ml 6% (w / v) KOH solution and add it to a 1...

Embodiment 2

[0028] When the present invention is specifically implemented, a preparation method of a drug-loaded pH-sensitive plant microcapsule nano-extruder specifically includes the following steps:

[0029] 1) A total of 25g of natural wild chrysanthemum and motherwort pollen were weighed and dissolved in 300~400ml of acetone, added to a 1000ml round-bottomed flask, stirred and refluxed in an oil bath at 70°C for 12 hours, and the solution was cooled and filtered under vacuum to obtain recovered pollen;

[0030] 2) Recover the pollen in step 1), dissolve it with 450ml 85% (w / w) phosphoric acid and add it to a 1000ml round-bottomed flask, stir and reflux for 12h in a 60°C oil bath, and the pollen solution is treated with phosphoric acid and then cooled and filtered, And successively wash with water, acetone, 2M HCl, 2M NaOH, water, acetone, 70% ethanol and suction filtration to obtain a suction filtration pollen;

[0031] 3) The pollen in step 2) was filtered by suction, dissolved in 350...

Embodiment 3

[0035] When the present invention is specifically implemented, a preparation method of a drug-loaded pH-sensitive plant microcapsule nano-extruder specifically includes the following steps:

[0036] 1) A total of 30g of natural wild chrysanthemum, motherwort, and sunflower pollen were weighed and dissolved in 400ml of acetone, added to a 1000ml round-bottomed flask, stirred and refluxed in an oil bath at 70°C for 12h, and the solution was cooled and filtered under vacuum to obtain recovered pollen;

[0037] 2) The pollen was recovered in step 1), dissolved in 500ml of 85% (w / w) phosphoric acid and added to a 1000ml round-bottomed flask, stirred and refluxed in a 60°C oil bath for 12h, the pollen solution was treated with phosphoric acid and then cooled and filtered, And successively wash with water, acetone, 2M HCl, 2M NaOH, water, acetone, 70% ethanol and suction filtration to obtain a suction filtration pollen;

[0038] 3) Filter the pollen with suction in step 2), dissolve ...

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Abstract

The invention relates to a preparation method and application of a pH-sensitive plant microcapsule nano extruder, which can effectively solve the problem of treatment of diabetes mellitus, and adopts the technical scheme that the preparation method of the drug-loaded pH-sensitive plant microcapsule nano extruder comprises the following steps: adopting pollen grains which are natural, green, high in biocompatibility and sugar adsorbability; the preparation method comprises the following steps: extracting allergen-free pollen shells as a basic material through a chemical treatment method, ultrasonically stirring, selecting insulin as a hypoglycemic drug by utilizing a strong electrostatic interaction force between rich free carboxyl groups of gamma-polyglutamic acid and a large amount of amino groups of chitosan under an acidic condition, and self-assembling to prepare nanogel which is loaded in the pollen shells. According to the pH-sensitive plant microcapsule nanoparticle extruder disclosed by the invention, the medicine can be accurately positioned in the small intestine, insulin can be continuously released to play a treatment role, and the pH-sensitive plant microcapsule nanoparticle extruder is a great innovation on the microcapsule nanoparticle extruder.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method and application of a pH-sensitive plant microcapsule nano extruder. Background technique [0002] According to the "2021IDF Global Diabetes Map (10th Edition)" released by the International Diabetes Federation (IDF), the number of adults with diabetes in the world will reach 537 million (10.5%) in 2021. affected. The health burden of diabetes is definitely a major challenge for individuals, families and societies. Although in the past few decades, blood sugar control has been achieved by subcutaneous injection of insulin in diabetic patients, but maintaining normal blood sugar through such painful injections for a long time has seriously affected the daily life of diabetic patients. In addition, when subcutaneously injected, insulin is circulated in the body through peripheral circulation. mobile, which can produce peripheral hyperinsulinemia, so it is nec...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K47/46A61K38/28A61K47/36A61P3/10
CPCA61K38/28A61K9/5068A61K9/0053A61K47/36A61P3/10A61K9/5161Y02A50/30
Inventor 张红岭李静王明金王兵华路翔范培博
Owner ZHENGZHOU UNIV
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