Preparation method of medicinal plant extract for reducing blood sugar and application in pharmacy and health food thereof

A technology of medicinal plants and extracts, applied in the preparation of medicinal plants-wild pineapple hypoglycemic extract and its active parts, in the development of pharmaceuticals and health care products, and can solve problems such as inability to achieve a radical cure

Inactive Publication Date: 2014-05-14
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Since diabetes is a systemic disease with very complicated etiology, which involves changes in multiple physiological systems such as glucose metabolism, lipid metabolism, and immune response, Western medicines with relatively single ingredients and therapeutic targets can improve diabetes

Method used

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  • Preparation method of medicinal plant extract for reducing blood sugar and application in pharmacy and health food thereof
  • Preparation method of medicinal plant extract for reducing blood sugar and application in pharmacy and health food thereof
  • Preparation method of medicinal plant extract for reducing blood sugar and application in pharmacy and health food thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Preparation of medicinal plant extracts and effective parts thereof in the present invention (1)

[0026] Take fresh and ripe wild pineapple, put it in a container, add 10-20 times of water, soak for 2 hours, decoct 3 times for 2 hours each time, filter, concentrate until dry to obtain the medicinal plant extract. After the medicinal plant extract is dissolved in water, it is separated by D-101 macroporous adsorption resin, eluted with different concentrations of ethanol-water solution until it is colorless, and the eluate is concentrated under reduced pressure to obtain the water eluate, 70% The ethanol eluate is concentrated and spray-dried to obtain the effective fraction of the present invention.

Embodiment 2

[0027] Example 2 Preparation of medicinal plant extracts and effective parts thereof in the present invention (two)

[0028] Take the freshly matured wild pineapple which has been dried in the shade, put it in a container, add 10-20 times of ethanol or ethanol-water (7:3), soak for 2 hours, reflux extraction for 3 times, each time for 2 hours, filter, and concentrate until dry. Medicinal plant extracts. After the medicinal plant extract is dissolved in water, degreased by the organic solvent chloroform or ethyl acetate, it is repeatedly extracted with n-butanol until it is colorless, the extract is concentrated under reduced pressure, and spray-dried to obtain the effective part of the present invention .

Embodiment 3

[0029] Embodiment 3 The influence of the medicinal plant extract of the present invention on the insulin tolerance of spontaneous diabetic mice

[0030] 3.1. Test materials: wild pineapple water extract, metformin, high-fat feed, Roche automatic blood glucose meter

[0031] 3.2. Test animals: db / db spontaneous diabetic mice (30-40g)

[0032] 3.3. Test method: Take 60 male db / db spontaneous diabetic mice of 30-40g, and randomly divide them into three dosage groups of hyperglycemia model group, metformin positive control group and wild pineapple water extract (doses are respectively 50mg / kg, 100mg / kg, 200mg / kg), 100mg / kg metformin group, a total of 5 groups (12 rats), all were fed high-fat feed, and the corresponding drugs were given by intragastric administration at the same time, and the hyperglycemia model group was intragastrically administered the same volume of tap water. After 3 weeks of administration, the mice in each group were fasted for 4 hours, and 0.8 U / kg insulin...

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Abstract

The invention relates to a preparation method of a medicinal plant extract and an application in pharmacy and health food thereof. The medicinal plant extract is prepared by using a medicinal plant of pandanus tectorius (the fruit of pandanus tectorius) in south of the Five Ridges as a raw material, and is prepared by extraction and separation. The preparation method comprises: extracting the pandanus tectorius with water or/and alcohol, concentrating and drying the extract liquid to obtain the extract of the invention. The extract is dissolved in water, and degreased; the extract is extracted by an organic solvent to obtain an extraction part; or the extract is treated by macroporous adsorption resin, and is eluted by water, methanol, ethanol, acetone or a 60-90% ethanol or acetone aqueous solution; the extract or extracted liquid or eluate is collected, recovered at a reduced pressure, concentrated into extract, and dried to obtain effective part of the medicinal plant extract of the invention. The traditional Chinese medicine extract is proved to have blood sugar reduction effect by various pharmacodynamic experiments, can be used to prepare drugs or health products for reducing blood sugar, and can be used to treat diabetes and related complications.

Description

technical field [0001] The invention relates to the fields of pharmacy and health food, in particular to a preparation method of a hypoglycemic medicinal plant-wild pineapple hypoglycemic extract and its active part and its application in the development of pharmacy and health care products. Background technique [0002] With the progress of society and the change of lifestyle, the incidence of metabolic diseases such as diabetes is increasing year by year. According to statistics, in 2010, the total number of diabetic patients in the world was 285 million, accounting for 6.4% of the world's adult population, and more than 3.8 million people died of diabetes-related diseases every year. In my country, the incidence of diabetes is about 9.7%, which is much higher than the world average. In 2011, the total number of diabetic patients in my country was close to 100 million, and about 50 million people were on the verge of diabetes. Facing such a severe trend of diabetes, findi...

Claims

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Application Information

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IPC IPC(8): A61K36/88A23L1/29A61P3/10A61K131/00A23L33/00
Inventor 郭鹏许旭东张小坡吴崇明
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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