Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for preparing caffeoylquinic acid

A technology of caffeoylquinic acid and solvent gasoline, which is applied in the preparation of carboxylate, chemical instruments and methods, preparation of organic compounds, etc., and can solve problems such as industrial separation and discussion

Inactive Publication Date: 2014-02-12
TAIZHOU XINWEI CHEM
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In fact, Artemisia annua contains not only artemisinin, but also caffeoylquinic acid (Jian Han, Min Ye, Xue Qiao, Man Xu, Bao-rong Wang, De-An Guo. Characterization of phenolic compounds in the Chinese herbal drug Artemisia annua by liquid chromatography coupled to electrospray ionization mass spectrometry. 2008, (47): 516-525), but this literature only identified caffeic acid quinic acid in the methanol extract class of substances, it was not quantified, nor was the extraction

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Take 100g of the industrial extraction residue of Artemisia annua after extracting artemisinin with solvent gasoline, and add it into a solution with pH=9.0 and isopropanol:water=8:1 at a solid-to-liquid ratio of 1:100 (w / w). Assisted leaching for 0.5 hours, after solid-liquid separation, the extract containing caffeoylquinic acid was obtained, and 4.0 g of caffeoylquinic acid with a purity of 56% was obtained through liquid-liquid extraction, and then separated and purified by a chromatographic column to obtain a pure 93% Caffeoylquinic Acid 1.8g.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a method for preparing caffeoylquinic acid, which comprises the following steps of fetching 100g of artemisia annua industrial extraction remainder obtained after extracting artemisinin with a solvent gasoline, and adding into a solution of which the pH is 9.0 and the isopropyl alcohol-water ratio is 8:1 according to a solid-liquid ratio of 1:100 (w / w); leaching for 0.5 hour under microwave assistance; performing solid-liquid separation to obtain extraction liquid containing caffeoylquinic acid; performing liquid-liquid extraction separation to obtain 4.0g of caffeoylquinic acid with purity of 56%; separating through a chromatographic column and purifying to obtain 1.8g of caffeoylquinic acid with purity of 93%.

Description

technical field [0001] The invention relates to a method for preparing caffeoylquinic acid. Background technique [0002] Artemisia annua is a plant of Compositae Artemisia annua L The dry aerial part of . has the effects of clearing heat, detoxifying, and antimalarial. Artemisinin is an active ingredient extracted from Artemisia annua, and it is the only new antimalarial drug internationally recognized in my country. [0003] Artemisia annua is rich in resources in my country, but the current industrial utilization of Artemisia annua is only a product of extracting artemisinin (Li Shiyu, Qi Xiangjuan, He Yujuan. Method for extracting and isolating artemisinin from Artemisia annua plants. CN200510015146.4). Other utilization of Artemisia annua resources mostly stays in Artemisia annua tea, compound granule (Xiao Wei, Wang Zhenzhong and Bi Yuan. A method for the content determination of Chinese patent medicine made from Artemisia annua, honeysuckle and gardenia. CN: 2010101...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C69/732C07C67/56C07C67/48
CPCC07C67/48
Inventor 苗陵生
Owner TAIZHOU XINWEI CHEM
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com