Method for preparing caffeoylquinic acid
A technology for extraction of caffeoylquinic acid and petroleum ether, which can be used in the separation/purification of carboxylate, organic chemistry, etc., and can solve problems such as industrial separation and discussion
Inactive Publication Date: 2014-02-12
TAIZHOU XINWEI CHEM
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Problems solved by technology
Another literature reported that artemisinin and caffeoylquinic acid compounds were identified in the aqueous solution of Artemisia annua tea by liquid chromatography-mass spectrometry, in which the content of dicaffeoylquinic acid was 1.54%, and the total caffeoylquinic acid The content is 2.56%. But there is no discussion on industrial separation (Teresa Carbonara, Rossana Pascale, Maria Pia Argentieri, Paride Papadia, Francesco Paolo Fanizzi, Luciano Villanova, Pinarosa Avato. Phytochemical analysis of a herbal tea from Artemisia annua L. Journal of Pharmaceutical and Biomedical Analysis. 2012. (62):79-86)
Method used
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Experimental program
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Effect test
Embodiment 1
[0012] Take 100g of the industrial extraction residue of Artemisia annua after extracting artemisinin with petroleum ether, add it into a solution with pH=1.0, n-butanol:water=9:1 at a solid-to-liquid ratio of 1:5 (w / w), and ultrasonically Leaching under the action for 10 hours, after solid-liquid separation, the extract containing caffeoylquinic acid was obtained, and 3.5g of caffeoylquinic acid with a purity of 61% was obtained through liquid-liquid extraction, and then separated and purified by a chromatographic column to obtain a purity 94% Caffeoylquinic Acid 1.5g.
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The invention relates to a method for preparing caffeoylquinic acid, which comprises the following steps of fetching 100g of artemisia annua industrial extraction remainder obtained after extracting artemisinin with petroleum ether, and adding into a solution of which the pH is 1.0 and the n-butyl alcohol-water ratio is 9:1 according to a solid-liquid ratio of 1:5 (w / w); leaching for 10 hours under ultrasonic effect; performing solid-liquid separation to obtain extraction liquid containing caffeoylquinic acid; performing liquid-liquid extraction separation to obtain 3.5g of caffeoylquinic acid with purity of 61%; separating through a chromatographic column and purifying to obtain 1.5g of caffeoylquinic acid with purity of 94%.
Description
technical field [0001] The invention relates to a method for preparing caffeoylquinic acid. Background technique [0002] Artemisia annua is a plant of Compositae Artemisia annua L The dry aerial part of . has the effects of clearing heat, detoxifying, and antimalarial. Artemisinin is an active ingredient extracted from Artemisia annua, and it is the only new antimalarial drug internationally recognized in my country. [0003] Artemisia annua is rich in resources in my country, but the current industrial utilization of Artemisia annua is only a product of extracting artemisinin (Li Shiyu, Qi Xiangjuan, He Yujuan. Method for extracting and isolating artemisinin from Artemisia annua plants. CN200510015146.4). Other utilization of Artemisia annua resources mostly stays in Artemisia annua tea, compound granule (Xiao Wei, Wang Zhenzhong and Bi Yuan. A method for the content determination of Chinese patent medicine made from Artemisia annua, honeysuckle and gardenia. CN: 2010101...
Claims
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IPC IPC(8): C07C69/732C07C67/48
CPCC07C67/48
Inventor 苗陵生
Owner TAIZHOU XINWEI CHEM
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