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Application of total saponins in unripe siraitia grosvenorii fruit extract in preparation of assistant hypoglycemic drug

A technology of Luo Han Guo extract and Mogroside, which is applied in the field of medicinal natural products and achieves the effects of abundant resources, simple and easy preparation method, and lowering postprandial blood sugar and fasting blood sugar

Active Publication Date: 2016-06-08
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] However, there is no report on the use of immature Luo Han Guo as a raw material to extract total saponins from Luo Han Guo, and to use the total saponins to prepare foods and medicines for the auxiliary treatment of insulin resistance and type Ⅱ diabetes

Method used

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  • Application of total saponins in unripe siraitia grosvenorii fruit extract in preparation of assistant hypoglycemic drug
  • Application of total saponins in unripe siraitia grosvenorii fruit extract in preparation of assistant hypoglycemic drug
  • Application of total saponins in unripe siraitia grosvenorii fruit extract in preparation of assistant hypoglycemic drug

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Effect test

Embodiment 1

[0034] The application of total saponins in immature momordica grosvenori extract in the preparation of auxiliary hypoglycemic drugs, the main effective components of the total saponins in the immature momordica grosvenori extract are mogroside Ⅱ, mogroside Ⅲ or both The structure of the mixture is as follows:

[0035] Ⅱ

[0036]

[0037] Ⅲ

[0038]

[0039] Among them, the mixture of mogroside II and mogroside III is mixed in any ratio.

[0040] The extraction method of the immature Momordica grosvenori extract is: take the dried immature Momordica grosvenori fruit with a growth period of 30 days, crush it, add pure water at 1:1 times the weight of the medicinal material, and extract 1 to 3 times until the sample is completely submerged Extraction for 2~10h each time, keep the temperature at 40℃, combine the filtrate and concentrate; add 1~2 times the volume of the filtrate to the filtrate, extract 1~3 times, adsorb with D101 macroporous resin column, and then use pure Rinse with w...

Embodiment 2

[0045] The application of total saponins in immature momordica grosvenori extract in the preparation of auxiliary hypoglycemic drugs, the main effective components of the total saponins in the immature momordica grosvenori extract are mogroside Ⅱ, mogroside Ⅲ or both The structure of the mixture is as follows:

[0046] Ⅱ

[0047]

[0048] Ⅲ

[0049]

[0050] Among them, the mixture of mogroside II and mogroside III is mixed in any ratio.

[0051] The extraction method of the immature Momordica grosvenori extract is: take the dried immature Momordica grosvenori fruit with a growth period of 50 days, crush it, add pure water at 1:5 times the weight of the medicinal material, and extract 1 to 3 times until the sample is completely submerged Extraction for 2~10h each time, keep the temperature at 70℃, combine the filtrate and concentrate; add 1~2 times the volume of the filtrate to the filtrate, extract 1~3 times, adsorb with D101 macroporous resin column, and then use pure Rinse with w...

Embodiment 3

[0056] The application of total saponins in immature momordica grosvenori extract in the preparation of auxiliary hypoglycemic drugs, the main effective components of the total saponins in the immature momordica grosvenori extract are mogroside Ⅱ, mogroside Ⅲ or both The structure of the mixture is as follows:

[0057] Ⅱ

[0058]

[0059] Ⅲ

[0060]

[0061] Among them, the mixture of mogroside II and mogroside III is mixed in any ratio.

[0062] The extraction method of the immature Momordica grosvenori extract is: take the dried immature Momordica grosvenori fruit with a growth period of 80 days, crush it, add pure water at 1:9 times the weight of the medicinal material, and extract 1 to 3 times until the sample is completely submerged Extraction for 2~10h each time, keep the temperature at 90℃, combine the filtrate and concentrate; add 1~2 times the volume of the filtrate to the filtrate, extract 1~3 times, adsorb with D101 macroporous resin column, and then use pure Rinse with w...

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Abstract

The invention relates to application of total saponins in unripe siraitia grosvenorii fruit extract in preparation of an assistant hypoglycemic drug. Extract containing the total saponins with the content by weight of 60%-90% is extracted from unripe siraitia grosvenorii fruit with the growing period of 30 days-80 days, one of the effective ingredients mogroside II and mogroside III in the total saponins or a mixture of the effective ingredients mogroside II and mogroside III in the total saponins inhibits the activity of alpha-glucosidase in vitro and in vivo, the fasting blood-glucose level and the postprandial blood glucose level of a type-II diabetic mouse are lowered, and the activity of the insulin resistance index is reduced; in addition, new application of the total saponins in preparation of food or the drug for assisting in treating insulin resistance and type-II diabetes mellitus is achieved.

Description

Technical field [0001] The invention belongs to the field of medicinal natural products, and in particular relates to the application of Luo Han Guo total saponins extracted from immature Luo Han Guo to assist in lowering blood sugar activity and in preparing food or medicines with auxiliary treatment to improve insulin resistance and treat type II diabetes. Background technique [0002] Diabetes is a common and frequently-occurring disease, and its incidence has been on the rise in recent years. The mortality rate of diabetes is second only to tumor diseases and cardiovascular diseases, and ranks third among diseases threatening human health. Currently, there are many varieties of oral hypoglycemic drugs for the treatment of diabetes, but the long-term application of most oral hypoglycemic drugs has obvious adverse effects, and cannot take into account the control of postprandial blood glucose and fasting basal blood glucose level. Insulin sensitizers represented by thiazolidino...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704C07J17/00A61K36/42A61P3/10A61P5/50A23L33/125
CPCA23V2002/00A61K31/704A61K36/42C07J17/005A23V2200/328A23V2250/21
Inventor 夏星王勤李宇清钟静何伟平朱晓韵
Owner GUANGXI UNIV OF CHINESE MEDICINE
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