Application of frankincense pentacyclic triterpenic acid compound or salt and combination to preparation of diabetes treating medicine

The technology of a compound and triterpene acid, which is applied in the field of medicine, can solve problems such as reports on the pharmacological effects of boswellic acid compounds on lowering blood sugar.

Inactive Publication Date: 2016-11-23
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Published research papers and open patents have no report on the pharmacological effects of boswellic acid compounds on hypoglycemia

Method used

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  • Application of frankincense pentacyclic triterpenic acid compound or salt and combination to preparation of diabetes treating medicine
  • Application of frankincense pentacyclic triterpenic acid compound or salt and combination to preparation of diabetes treating medicine
  • Application of frankincense pentacyclic triterpenic acid compound or salt and combination to preparation of diabetes treating medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1. Therapeutic effect of boswellic acid compounds on dexamethasone-induced insulin resistance in mice

[0016] Experimental Materials:

[0017] Animal: Kunming mouse, male.

[0018] Test substances: IR06 (AKBA), content ≥98% (HPLC), IR10 (α, β-ABA 1:1 mixture), IR02 (boswellic acid extract, containing AKBA26.4%, α-ABA10.1%, β-ABA 15.7%), prepared by Innovation Center of Tianjin Pharmaceutical Research Institute,

[0019] Positive drug: Rosiglitazone, 4mg / tablet, batch number: 121001, Chengdu Hengrui Pharmaceutical Co., Ltd.

[0020] Instrument: blood glucose meter, model, FreeStyle Freedom, product of Abbott Diabetes Care Company.

[0021] experimental method:

[0022] Model preparation: mice, male, weighing 18-21g, fasted for 16 hours, measured fasting blood sugar, excluded animals with abnormal blood sugar, intramuscularly injected dexamethasone 2mg / kg, injected once a day, continuously injected for 14 days, blank control group was injected accordingly sa...

Embodiment 2

[0028] Example 2. The therapeutic effect of boswellic acid compounds on hereditary diabetes animal model (Kkay mice)

[0029] Experimental Materials:

[0030] Animals: Kkay mice, female. Purchased from Union Institute of Zoology, Chinese Academy of Medical Sciences;

[0031] Test substances: IR06 (AKBA), content ≥98% (HPLC), IR10 (α, β-ABA 1:1 mixture), IR02 (boswellic acid extract, containing AKBA26.4%, α-ABA10.1%, β-ABA 15.7%), prepared by the Innovation Center of Tianjin Pharmaceutical Research Institute;

[0032] Positive drug: Rosiglitazone, 4mg / tablet, batch number: 121001, Chengdu Hengrui Pharmaceutical Co., Ltd.;

[0033] Instrument: blood glucose meter, model, FreeStyle Freeβdom, product of Abbott Diabetes Care.

[0034] experimental method:

[0035] Model preparation: Kkay mice were fed adaptively for 1 week and weighed 26-33g. Blood was collected from the tail vein to measure the blood glucose level randomly, and the random blood glucose level reached the stand...

Embodiment 3

[0043] 100g of frankincense resin, add 1L of medicinal ethanol for reflux extraction for 1.5 hours each time, extract continuously for 2 times, combine the extracts, concentrate to about 300ml, add 700ml of 5% sodium carbonate solution to disperse and suspend, and use petroleum ether-ethyl acetate (3: 2) Extract 3 times, adjust the pH of the water layer to 3-4 with 10% HCl, extract 4 times with ethyl acetate, combine the ethyl acetate layers, wash with water until the water is neutral, add anhydrous Dehydrated with sodium sulfate and concentrated to dryness to obtain 32 g of boswellic acid refined extract (IR02).

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to an application of a frankincense pentacyclic triterpenic acid compound, pharmaceutically acceptable salt and combination containing the compound or the salt to preparation of a diabetes treating medicine. The compound and the combination thereof or the salt shows good blood glucose reducing functions for different insulin diabetes resistance animal models, and can possibly serve as an insulin sensitizing agent blood glucose reducing medicine for overcoming limitation of an existing medicine.

Description

[0001] Technical field: the present invention belongs to the technical field of medicine, and specifically relates to the use of boswellia pentacyclic triterpene acid compounds and pharmaceutically acceptable salts thereof, and compositions containing the compounds or salts in the preparation of diabetes treatment drugs. Background technique: [0002] Type 2 diabetes is a common metabolic disease characterized by the body's inability to produce sufficient amounts of insulin and is often accompanied by defective insulin action. Insulin resistance is an important etiology and a significant feature of type 2 diabetes, and research on drugs that improve insulin resistance or increase insulin sensitivity has important clinical significance. At present, the most representative clinical insulin sensitizers are mainly thiazolidinediones, but these drugs have different degrees of hepatotoxicity (such as troglitazone withdrawn from the market due to hepatotoxicity) and cardiovascular ris...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00A61K31/56A61P3/10
Inventor 韩英梅于冰赵娜夏
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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