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Use of resveratrol dimer for preparing medicament for reducing blood sugar

A technology for lowering blood sugar and usage, which is applied in the field of medical application of resveratrol dimer, and can solve the problems of unreported other activities and strong antioxidant effect

Inactive Publication Date: 2009-05-20
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

(P. Longcake, and P. J. Pryce. Experientia. 33, 151 (1977); H. Kurihara, J. Kawabata, S. Ichikawa, and J. Mizutani. Agric. Biol. Chem. 54, 1097-1099 (1990)) At present, the reports on the activity of this compound are limited to the strong antioxidant effect, and the other activities have not been reported.

Method used

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  • Use of resveratrol dimer for preparing medicament for reducing blood sugar
  • Use of resveratrol dimer for preparing medicament for reducing blood sugar
  • Use of resveratrol dimer for preparing medicament for reducing blood sugar

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] α-glucosidase activity assay:

[0015] According to the method of Pierre et al. (C.Pierre, R.Roland, D.Tremblay.J Clin Chem, 24, 208-211 (19780), with p-nitrophenyl β-D-galactopyranoside (PNPG) as base α-glucosidase activity was measured. The reaction system was: 10 μl 1U / ml α-D-glucosidase (with KH 2 PO 4 -K 2 HPO 4 Buffer solution preparation, pH = 6.8) Add 100 μl of buffer solution and incubate at 37°C for 10 minutes, then add 90 μl of 0.01mol / L PNPG and incubate at 37°C for 10 minutes, and measure the absorption with a 410 nm microplate reader. The enzyme activity unit is defined as: the amount of enzyme required to hydrolyze PNPG to release 1 μmol p-nitrophenol (PNP) within 1 min under the conditions of 37°C and pH 6.8. Determination of inhibition of α-glucosidase activity: samples of different concentrations were added with 10 μl 1U / ml α-D-glucosidase (using KH 2 PO 4 -K 2 HPO 4 Prepare buffer solution, pH=6.8), add 50 μl of buffer solution and incubate at...

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Abstract

The invention relates to the pharmacy field, in particular to medical application of resveratrol dimer. Pharmaceutical researches prove that the resveratrol dimer has obvious effect on inhibiting alpha-glucosaccharase, and can be used as hypoglycemic drugs, hypoglycemic health care foods or hypoglycemic foods.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the medical application of a resveratrol dimer. Background technique [0002] Diabetes mellitus (diabetes mellitus) is a metabolic disease group characterized by chronically elevated blood glucose (referred to as blood sugar) levels. The main features are hyperglycemia, diabetes, polyuria, polydipsia, polyphagia, weight loss, and fatigue. Diabetes is one of the most common chronic diseases. With the improvement of people's living standards, the aging population and the increase in the incidence of obesity, the incidence of diabetes is increasing year by year. At present, there are more than 20 million people with diabetes in the country, and nearly 20 million people with impaired glucose tolerance. The total number of people with diabetes ranks second in the world. If not controlled, by 2025 my country's diabetes patients may reach 60 million people. [0003] Diabetes is divided into...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61P3/10A23L1/30A23L33/10
Inventor 孔令义万翔马丽王小兵
Owner CHINA PHARM UNIV
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